Robert M E, Leung F W, Guth P H
Dig Dis Sci. 1986 May;31(5):530-4. doi: 10.1007/BF01320320.
The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after treatment with either intravenous nicotine (4 or 40 micrograms/kg/min) or inhaled cigarette smoke (nicotine or nicotine free). Neither intravenous nicotine nor cigarette smoke significantly altered gastric mucosal blood flow. On the other hand, hypotension produced by hemorrhage significantly decreased mucosal blood flow (P less than 0.05). Thus the technique used could detect a decrease in blood flow. These findings indicate that in the anesthetized rats, hypotension but not intravenous nicotine or cigarette smoke, in the doses given, reduce gastric mucosal blood flow.
关于尼古丁和香烟烟雾对胃血流量影响的文献存在矛盾。采用氢气清除技术来测量尼古丁和香烟烟雾对麻醉大鼠基础胃黏膜血流量的影响。在用静脉注射尼古丁（4或40微克/千克/分钟）或吸入香烟烟雾（含尼古丁或不含尼古丁）进行治疗之前、期间和之后测量血流量。静脉注射尼古丁和香烟烟雾均未显著改变胃黏膜血流量。另一方面，出血引起的低血压显著降低了黏膜血流量（P<0.05）。因此，所使用的技术能够检测到血流量的减少。这些发现表明，在麻醉大鼠中，低血压而非给定剂量的静脉注射尼古丁或香烟烟雾会降低胃黏膜血流量。
