Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Nat Commun. 2023 Mar 29;14(1):1746. doi: 10.1038/s41467-023-37407-x.
Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for 2.4 months. Following two-dose series of measles-containing vaccine (MCV) at 8 and 18 months of age, the immune protection against measles is not lifelong, and antibody concentrations are extrapolated to fall below the protective threshold of 200 mIU/ml at 14.3 years. A catch-up MCV dose in addition to the routine doses between 8 months and 5 years reduce the cumulative incidence of seroreversion by 79.3-88.7% by the age of 6 years. Our findings also support a good immune response after the first MCV vaccination at 8 months. These findings, coupled with the effectiveness of a catch-up dose in addition to the routine doses, could be instrumental to relevant stakeholders when planning routine immunization schedules and supplemental immunization activities.
描述母体来源和疫苗诱导的麻疹免疫力的长期动力学对于指导未来的麻疹免疫策略至关重要。基于中国的两个前瞻性队列儿童研究，我们估计麻疹的母体来源免疫力可维持 2.4 个月。在 8 个月和 18 个月龄时接种两剂含麻疹疫苗（MCV）后，麻疹的免疫保护并非终身的，抗体浓度预计在 14.3 岁时降至 200 mIU/ml 的保护阈值以下。在 8 个月至 5 岁期间常规接种剂量之外再接种一剂 MCV 可将 6 岁时血清学转换的累积发生率降低 79.3-88.7%。我们的研究结果还支持 8 个月时初次接种 MCV 后的良好免疫反应。这些发现，加上常规剂量之外的补种剂量的有效性，在规划常规免疫计划和补充免疫活动时，可能对相关利益攸关方具有重要意义。
