Al Hakeem Walid Ghazi, Acevedo Villanueva Keila Y, Selvaraj Ramesh K
Department of Poultry Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USA.
Vaccines (Basel). 2023 Mar 5;11(3):595. doi: 10.3390/vaccines11030595.
The gut is home to more than millions of bacterial species. The gut bacteria coexist with the host in a symbiotic relationship that can influence the host's metabolism, nutrition, and physiology and even module various immune functions. The commensal gut microbiota plays a crucial role in shaping the immune response and provides a continuous stimulus to maintain an activated immune system. The recent advancements in high throughput omics technologies have improved our understanding of the role of commensal bacteria in developing the immune system in chickens. Chicken meat continues to be one of the most consumed sources of protein worldwide, with the demand expected to increase significantly by the year 2050. Yet, chickens are a significant reservoir for human foodborne pathogens such as Understanding the interaction between the commensal bacteria and is essential in developing novel technologies to decrease load in broilers. This review aims to provide current knowledge of gut microbiota development and its interaction with the immune system in broilers. Additionally, the effect of infection on the gut microbiota is addressed.
肠道中存在着数百万种细菌。肠道细菌与宿主共生，这种共生关系会影响宿主的新陈代谢、营养和生理机能，甚至调节各种免疫功能。共生肠道微生物群在塑造免疫反应中起着关键作用，并持续提供刺激以维持免疫系统的激活状态。高通量组学技术的最新进展增进了我们对共生细菌在鸡免疫系统发育中作用的理解。鸡肉仍然是全球消费最多的蛋白质来源之一，预计到2050年需求将大幅增加。然而，鸡是人类食源性病原体的重要宿主，比如了解共生细菌与……之间的相互作用对于开发新技术以降低肉鸡体内……负荷至关重要。本综述旨在提供关于肉鸡肠道微生物群发育及其与免疫系统相互作用的当前知识。此外，还探讨了……感染对肠道微生物群的影响。 （注：原文中部分内容缺失，已按完整可译部分翻译）
