Mann D D, Buening G M, Hook B S, Osweiler G D
Infect Immun. 1982 Jun;36(3):1249-52. doi: 10.1128/iai.36.3.1249-1252.1982.
The effect of a Fusarium metabolite, T-2 toxin, on the bovine humoral immune system was explored during high-level, chronic administration. T-2 toxin administered to calves for 43 days at the rate of 0.6 mg/kg per day was associated with alterations of serum protein fractions, immunoglobulin levels, and C3 levels. Significant reductions in the levels of alpha, beta 1, beta 2, and gamma globulins, but not albumin, occurred after T-2 toxin administration. Likewise, a decline in C3 and serum immunoglobulin levels were evident. The levels of immunoglobulin M and immunoglobulin A, but not immunoglobulin G, in toxin-treated calves were significantly lower than control levels.
在高剂量、长期给药期间，研究了镰刀菌代谢产物T-2毒素对牛体液免疫系统的影响。以每天0.6毫克/千克的剂量给犊牛注射T-2毒素，持续43天，这与血清蛋白组分、免疫球蛋白水平和C3水平的改变有关。注射T-2毒素后，α、β1、β2和γ球蛋白水平显著降低，但白蛋白水平未降低。同样，C3和血清免疫球蛋白水平也明显下降。毒素处理的犊牛体内免疫球蛋白M和免疫球蛋白A的水平显著低于对照水平，但免疫球蛋白G的水平并非如此。
