Bergan T, Skjerven O
Infection. 1979;7(1):14-6. doi: 10.1007/BF01640549.
In a double blind, randomized study, sulfamethoxazole was compared alone and in combination with trimethoprim as commonly used in therapeutic regimes for the treatment of uncomplicated acute urinary tract infections in out-patients. The cure of sulfamethoxazole alone was 92.2%, and for sulfamethoxazole plus trimethoprim 97.6%. The rate of side-effects for the former was 5%, for the latter 21.8%. If the failure rate plus the rate of occurrence of rash, which necessitated discontinuing the drug, are combined, it appears that 8.8% of the patients were at a disadvantage receiving sulfamethoxazole compared to 9.7% for the combination of sulfamethoxazole plus trimethoprim. When considering the cure rate and rate of side-effects together, therefore, the position of sulfamethoxazole alone as a suitable drug in this type of infection is defended.
在一项双盲随机研究中，对单独使用磺胺甲恶唑以及将其与甲氧苄啶联合使用（这是治疗门诊非复杂性急性尿路感染的常用治疗方案）进行了比较。单独使用磺胺甲恶唑的治愈率为92.2%，磺胺甲恶唑加甲氧苄啶的治愈率为97.6%。前者的副作用发生率为5%，后者为21.8%。如果将失败率加上因皮疹而必须停药的发生率合并计算，与磺胺甲恶唑加甲氧苄啶联合用药的9.7%相比，接受磺胺甲恶唑治疗的患者中似乎有8.8%处于劣势。因此，综合考虑治愈率和副作用发生率，单独使用磺胺甲恶唑作为这类感染的合适药物是合理的。
