A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky pr. 49, Moscow, Russian Federation, 119334.
Department of Materials Science, M.V. Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russian Federation, 119991.
J Mater Sci Mater Med. 2021 Aug 18;32(9):99. doi: 10.1007/s10856-021-06575-x.
For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
对于骨替代材料，人们希望其具有骨传导性、骨诱导性和骨生成性。细菌耐药性以及对新的抗菌策略的需求是现代医学最具挑战性的任务之一。在这项工作中，制备并研究了基于锌（Zn）（1.4wt%）取代的磷酸三钙（β-TCP）和未取代的β-TCP 粉末的磷酸钙骨水泥。报告了它们的初始和最终相组成、凝固时间、形态、pH 值演变和抗压强度。在生理溶液中浸泡 60 天后，水泥转变为水合磷酸钙和羟磷灰石的混合物。水泥对粪肠球菌、大肠杆菌和铜绿假单胞菌的抗菌活性得到了证明。水泥对小鼠成纤维细胞 NCTC L929 细胞无细胞毒性。此外，与不含锌的β-TCP 水泥相比，含锌离子的β-TCP 水泥上的细胞活力高 10%。开发的水泥有望在矫形和创伤学中得到应用。
