Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland; Biomedicine PhD Program, University of Zurich, Switzerland.
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Stem Cell Res. 2023 Jun;69:103084. doi: 10.1016/j.scr.2023.103084. Epub 2023 Mar 27.
Attention-deficit hyperactivity disorder is a neurodevelopmental disorder which prevalence has been increasing in the past decades, affecting more than 5% of children, adolescents worldwide. Regarding etiology, polygenic, environmental factors contribute to the occurrence of ADHD even though molecular mechanisms are not known. Understanding the pathophysiology in patient-specific cells is crucial for the discovery of potential predictive markers, the establishment of new therapeutic targets. In this study, we generated further lines from ADHD patients, healthy controls using Sendai virus transduction, which may help on the study of ADHD at the molecular, cellular levels.
注意缺陷多动障碍是一种神经发育障碍，在过去几十年中患病率一直在上升，影响了全球超过 5%的儿童和青少年。关于病因，多基因和环境因素都可能导致 ADHD 的发生，尽管目前还不清楚其分子机制。了解患者特定细胞中的病理生理学对于发现潜在的预测标志物、建立新的治疗靶点至关重要。在这项研究中，我们使用仙台病毒转导从 ADHD 患者和健康对照中进一步生成了细胞系，这可能有助于在分子和细胞水平上研究 ADHD。
