Malgundkar Shika Hanif, Tamimi Yahya
Department of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Muscat, Sultanate of Oman.
Future Sci OA. 2023 Mar 6;9(1):FSO833. doi: 10.2144/fsoa-2022-0032. eCollection 2023 Jan.
More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.
超过三分之二的上皮性卵巢癌（EOC）患者因缺乏敏感的生物标志物而在晚期被诊断出来。目前，外泌体作为非侵入性癌症诊断标志物受到广泛研究。外泌体是释放到细胞外环境中的纳米囊泡，具有调节受体细胞行为的潜力。EOC细胞释放许多改变的外泌体货物，这些货物与肿瘤进展具有临床相关性。外泌体是强大的治疗工具（药物载体或疫苗），在不久的将来为临床治疗EOC提供了一个有前景的选择。在这篇综述中，我们强调了外泌体在细胞间通讯、上皮-间质转化（EMT）中的重要性，以及它们作为诊断和预后因素的潜力，特别是在EOC中。
