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血浆置换在溶血、肝酶升高和血小板减少(HELLP)综合征中的作用

Role of Plasmapheresis in Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome.

作者信息

Taj Sobaan, Mujtaba Mohamed, Miller Brett, Dandu Sowmaya, Austin Christopher P, Ali Akbar Usman, Sanekommu Harshavardhan, Hossain Mohammad A

机构信息

Internal Medicine, Jersey Shore University Medical Center, Neptune Township, USA.

Gastroenterology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

出版信息

Cureus. 2023 Feb 27;15(2):e35520. doi: 10.7759/cureus.35520. eCollection 2023 Feb.

DOI:10.7759/cureus.35520
PMID:37007368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10054188/
Abstract

Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is a rare abnormality comprising a series of symptoms that make up a syndrome. It usually happens during pregnancy or right after delivery. We describe a case of a 31-year-old female G4P2A2 (Gravida 4 Para 2 Abortions 2) who presented to the hospital for normal vaginal delivery but immediately postpartum developed HELLP syndrome. Acute fatty liver of pregnancy was a differential that the patient also met the criteria for. Her condition improved after starting her on plasmapheresis without considering hepatic transplantation. We emphasize distinguishing the overlap of symptoms between HELLP syndrome vs. acute fatty liver of pregnancy and the outcomes of plasmapheresis in managing HELLP syndrome without needing hepatic transplantation.

摘要

溶血、肝酶升高和血小板减少(HELLP)综合征是一种罕见的异常情况,由一系列症状组成一种综合征。它通常发生在孕期或产后不久。我们描述了一例31岁女性,孕4产2流2(孕4、产2、流产2),因正常阴道分娩入院,但产后立即发生了HELLP综合征。妊娠急性脂肪肝是该患者也符合其标准的鉴别诊断。在未考虑肝移植的情况下,对她开始进行血浆置换后病情有所改善。我们强调要区分HELLP综合征与妊娠急性脂肪肝症状的重叠情况,以及血浆置换在无需肝移植治疗HELLP综合征中的效果。

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Role of Plasmapheresis in Hemolysis, Elevated Liver Enzymes and Low Platelets (HELLP) Syndrome.血浆置换在溶血、肝酶升高和血小板减少(HELLP)综合征中的作用
Cureus. 2023 Feb 27;15(2):e35520. doi: 10.7759/cureus.35520. eCollection 2023 Feb.
2
[A comparison of clinical characteristics between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome].妊娠急性脂肪肝与溶血、肝酶升高和血小板减少综合征临床特征的比较
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022 Jun;34(6):624-629. doi: 10.3760/cma.j.cn121430-20220411-00361.
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Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome with acute cortical blindness.伴有急性皮质盲的溶血、肝酶升高和血小板减少(HELLP)综合征
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Am J Obstet Gynecol. 1994 Sep;171(3):799-804. doi: 10.1016/0002-9378(94)90101-5.

本文引用的文献

1
Liver Bleeding Due to HELLP Syndrome Treated With Embolization and Liver Transplantation: A Case Report and Review of the Literature.采用栓塞和肝移植治疗的HELLP综合征所致肝出血:一例报告并文献复习
Front Surg. 2021 Nov 22;8:774702. doi: 10.3389/fsurg.2021.774702. eCollection 2021.
2
Early diagnostic test for acute fatty liver of pregnancy: a retrospective case control study.早孕期急性 fatty liver of pregnancy 的诊断试验:一项回顾性病例对照研究。
BMC Pregnancy Childbirth. 2020 Mar 14;20(1):162. doi: 10.1186/s12884-020-2787-4.
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Liver Transplantation for Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome: A Propensity-score Matched Long-term Survival of the Scientific Registry of Transplant Recipients Dataset.
肝移植治疗溶血、肝酶升高和血小板计数低综合征:移植受者科学注册数据集倾向评分匹配的长期生存情况
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Diagnosis and Management of HELLP Syndrome Complicated by Liver Hematoma.并发肝血肿的HELLP综合征的诊断与管理
Clin Obstet Gynecol. 2017 Mar;60(1):190-197. doi: 10.1097/GRF.0000000000000253.
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Revisiting HELLP syndrome.再探HELLP综合征。
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A life-saving therapy in Class I HELLP syndrome: Therapeutic plasma exchange.I型HELLP综合征的一种挽救生命的疗法:治疗性血浆置换。
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Plasmapheresis: Lifesaving treatment in severe cases of HELLP syndrome.血浆置换:HELLP综合征严重病例的救命疗法。
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Acute fatty liver of pregnancy: an update on pathogenesis and clinical implications.妊娠期急性脂肪肝:发病机制及临床意义的最新进展
World J Gastroenterol. 2006 Dec 14;12(46):7397-404. doi: 10.3748/wjg.v12.i46.7397.
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HELLP syndrome: recognition and perinatal management.HELLP综合征:识别与围产期管理
Am Fam Physician. 1999 Sep 1;60(3):829-36, 839.
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HELLP syndrome.HELLP综合征。
Clin Obstet Gynecol. 1999 Jun;42(2):381-9. doi: 10.1097/00003081-199906000-00022.