School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Department of Chronic Non-Communicable Disease Control, Jiangsu Province Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Front Endocrinol (Lausanne). 2023 Mar 16;14:1140093. doi: 10.3389/fendo.2023.1140093. eCollection 2023.
Serum creatinine is associated with cardiovascular risk and cardiovascular events, however, the relationship between serum creatinine levels and cardiovascular risk is not well established in hypertensive population in Jiangsu Province. We aimed to evaluate the association of serum creatinine levels with traditional cardiovascular risk factors and 10-year cardiovascular risk in a Chinese hypertensive population.
Participants were patients with hypertension registered and enrolled in health service centers in 5 counties or districts from January 2019 to May 2020 in Jiangsu Province of China followed strict inclusion and exclusion criteria, demographics as well as clinical indicators and disease history and lifestyle were collected. Participants were divided into four groups according to quartiles of serum creatinine levels, then the China-PAR model was used to calculate 10-year cardiovascular risk for each individual.
A total of 9978 participants were enrolled in this study, 4173(41.82%) were males. The blood pressure level and prevalence of dyslipidemia, elderly, current smokers and drinking as well as obesity were higher in the Q4 group than the Q1 group (all < 0.05). Multivariable logistic regression showed that serum creatinine in the Q4 group compared with that in the Q1 group was positively associated with overweight and obesity (OR=1.432, 95% CI 1.237-1.658, <0.001), while negatively associated with physical activity (OR=0.189, 95%CI 0.165-0.217, <0.001), and so on. Multiple linear regression showed 10-year cardiovascular risk is positively associated with serum creatinine levels after adjusting for multiple risk factors (β=0.432, < 0.001).
Serum creatinine was associated with several traditional cardiovascular risk factors and the 10-year cardiovascular risk in hypertensive patients. Creatinine-reduction and kidney-sparing therapy are essential for patients with hypertension to optimize control of cardiovascular risk.
血清肌酐与心血管风险和心血管事件相关，但在江苏省的高血压人群中，血清肌酐水平与心血管风险的关系尚未得到充分证实。我们旨在评估血清肌酐水平与中国高血压人群中传统心血管危险因素和 10 年心血管风险的关系。
参与者为 2019 年 1 月至 2020 年 5 月期间根据严格的纳入和排除标准在中国江苏省的 5 个县或区的卫生服务中心登记和入组的高血压患者，收集了人口统计学特征以及临床指标、疾病史和生活方式。根据血清肌酐水平的四分位区间将参与者分为四组，然后使用中国 PAR 模型为每位个体计算 10 年心血管风险。
本研究共纳入 9978 名参与者，其中 4173 名（41.82%）为男性。与 Q1 组相比，Q4 组的血压水平以及血脂异常、老年人、现吸烟者和饮酒者以及肥胖的患病率较高（均 <0.05）。多变量 logistic 回归显示，与 Q1 组相比，Q4 组的血清肌酐与超重和肥胖呈正相关（OR=1.432，95%CI 1.237-1.658，<0.001），而与体力活动呈负相关（OR=0.189，95%CI 0.165-0.217，<0.001），等等。在调整了多种危险因素后，多元线性回归显示 10 年心血管风险与血清肌酐水平呈正相关（β=0.432，<0.001）。
血清肌酐与高血压患者的几种传统心血管危险因素和 10 年心血管风险相关。降低肌酐和保护肾脏的治疗对于高血压患者优化心血管风险控制至关重要。
