El Hajj Taghrid, Hassoun Mahmoud, Harb Ranime, Tarabay Oriana, Zarzour Amine, Zeineddine Maya
Neurology, Rafik Hariri University Hospital, Beirut, LBN.
Pulmonary and Critical Care Medicine, Rafik Hariri University Hospital, Beirut, LBN.
Cureus. 2023 Mar 1;15(3):e35633. doi: 10.7759/cureus.35633. eCollection 2023 Mar.
Concerns regarding potential neurologic complications of COVID-19 are being increasingly reported worldwide. Our objective was to investigate the neurologic complications of COVID-19 among a cohort of Lebanese patients with SARS-CoV-2 infection admitted to Rafik Hariri University Hospital (RHUH), the leading COVID-19 testing and treatment center in Lebanon.
This is a retrospective, single-center, observational study conducted from March to July 2020 at RHUH, Lebanon.
Of 169 hospitalized patients with confirmed SARS-CoV-2 infection (mean {SD} age was 45.75 {19} years and 62.7% were men), 91 patients (53.8%) had severe infection and 78 patients (46.2%) had non-severe infection according to the American Thoracic Society guidelines for community-acquired pneumonia. Overall, 112 patients (66.3%) developed neurologic symptoms: CNS (46.1%), PNS (43.7%), and skeletal muscle injury (2.4%). Compared with patients with non-severe infection, patients with severe infection were significantly older, were male and more likely to have underlying disorders, especially diabetes and cardiac or cerebrovascular disease. Moreover, those patients experienced more typical COVID-19 symptoms at onset of illness such as fever, cough and fatigue. However, there was no significant difference in the frequency of all nervous system manifestations between the severe and the non-severe infection groups (57 {62.6%} vs 55 {70.5%}; p =0.316), except for impaired consciousness, where seven patients had impaired consciousness in the severe group compared to none in the non-severe group (p=0.012).
A wide variety of neurologic symptoms were detected in our Lebanese cohort of hospitalized COVID-19 patients. A comprehensive knowledge of the neurologic manifestations will help healthcare providers to be more attentive to these complications.
全球范围内，关于新型冠状病毒肺炎（COVID-19）潜在神经并发症的担忧报告日益增多。我们的目的是调查黎巴嫩拉菲克·哈里里大学医院（RHUH）收治的一组感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的黎巴嫩患者中COVID-19的神经并发症情况，该医院是黎巴嫩主要的COVID-19检测和治疗中心。
这是一项于2020年3月至7月在黎巴嫩RHUH进行的回顾性、单中心观察性研究。
根据美国胸科学会社区获得性肺炎指南，169例确诊感染SARS-CoV-2的住院患者（平均{标准差}年龄为45.75{19}岁，62.7%为男性）中，91例患者（53.8%）为重症感染，78例患者（46.2%）为非重症感染。总体而言，112例患者（66.3%）出现神经症状：中枢神经系统（46.1%）、周围神经系统（43.7%）和骨骼肌损伤（2.4%）。与非重症感染患者相比，重症感染患者年龄显著更大，为男性，更可能有基础疾病，尤其是糖尿病以及心脏或脑血管疾病。此外，这些患者在疾病发作时出现更多典型的COVID-19症状，如发热、咳嗽和疲劳。然而，重症和非重症感染组所有神经系统表现的频率无显著差异（57{62.6%}对55{70.5%}；p = 0.316），但意识障碍除外，重症组有7例患者意识障碍，非重症组无（p = 0.012）。
在我们黎巴嫩住院COVID-19患者队列中检测到多种神经症状。全面了解神经表现将有助于医护人员更关注这些并发症。
