Wu Suqi, Liu Ketong, Zhou Bingyan, Wu Suwen
First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Front Cell Dev Biol. 2023 Mar 16;11:1164706. doi: 10.3389/fcell.2023.1164706. eCollection 2023.
As a medium among pregnant women, environment and fetus, placenta owns powerful and delicate epigenetic processes to regulate gene expression and maintain cellular homeostasis. N6-methyladenosine (mA) is the most prevalent modification that determines the fate of RNA, and its dynamic reversibility indicates that mA may serve as a sensitive responder to environmental stimuli. Emerging evidence suggests that mA modifications play an essential role in placental development and maternal-fetal crosstalk, and are closely related to gestational diseases. Herein, we summarized the latest techniques for mA sequencing and highlighted current advances of mA modifications in maternal-fetal crosstalk and the underlying mechanisms in gestational diseases. Therefore, proper mA modifications are important in placental development, but its disturbance mainly caused by various environmental factors can lead to abnormal placentation and function with possible consequences of gestational diseases, fetal growth and disease susceptibility in adulthood.
作为孕妇、环境和胎儿之间的媒介，胎盘拥有强大而精细的表观遗传过程来调节基因表达并维持细胞内稳态。N6-甲基腺苷（m6A）是决定RNA命运的最普遍修饰，其动态可逆性表明m6A可能作为环境刺激的敏感响应者。新出现的证据表明，m6A修饰在胎盘发育和母胎串扰中起重要作用，并且与妊娠疾病密切相关。在此，我们总结了m6A测序的最新技术，并强调了m6A修饰在母胎串扰中的当前进展以及妊娠疾病的潜在机制。因此，适当的m6A修饰在胎盘发育中很重要，但其主要由各种环境因素引起的干扰可导致胎盘形成和功能异常，可能导致妊娠疾病、胎儿生长以及成年期疾病易感性。
