HPV 整合可驱动肿瘤中病毒-宿主染色体外 DNA 的形成。
HPV Integration Can Drive the Formation of Virus-Host Extrachromosomal DNA in Tumors.
机构信息
Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
出版信息
Cancer Discov. 2023 Apr 3;13(4):814-816. doi: 10.1158/2159-8290.CD-23-0097.
Abstract
Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related article by Akagi et al., p. 910 (4).
摘要
人乳头瘤病毒（HPV）阳性癌细胞含有病毒和宿主 DNA，并表现出明显的基因组不稳定性。在本期《癌症发现》中，赤木和同事们描绘了 HPV 阳性细胞中病毒-宿主 DNA 分子的惊人复杂景观，为具有潜在驱动克隆进化能力的多种整合和染色体外病毒-宿主杂交 DNA 提供了证据。见 Akagi 等人的相关文章，第 910 页（4）。
相似文献
1
HPV Integration Can Drive the Formation of Virus-Host Extrachromosomal DNA in Tumors.HPV 整合可驱动肿瘤中病毒-宿主染色体外 DNA 的形成。
Cancer Discov. 2023 Apr 3;13(4):814-816. doi: 10.1158/2159-8290.CD-23-0097.
2
Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration.HPV 整合诱导的肿瘤内异质性和克隆进化。
Cancer Discov. 2023 Apr 3;13(4):910-927. doi: 10.1158/2159-8290.CD-22-0900.
3
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer.HPV 癌基因仅从多个整合的 HPV DNA 拷贝中的一个表达，驱动宫颈癌中的克隆细胞扩增。
mBio. 2024 May 8;15(5):e0072924. doi: 10.1128/mbio.00729-24. Epub 2024 Apr 16.
4
Genome Instability Precedes Viral Integration in Human Papillomavirus-Transformed Tonsillar Keratinocytes.在人乳头瘤病毒转化的扁桃体角质形成细胞中，基因组不稳定先于病毒整合发生。
Mol Cancer Res. 2025 Feb 6;23(2):119-127. doi: 10.1158/1541-7786.MCR-24-0604.
5
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer.长读测序揭示了宫颈癌中 HPV 整合的高分辨率及其致癌进展。
Nat Commun. 2022 May 10;13(1):2563. doi: 10.1038/s41467-022-30190-1.
6
Type-dependent integration frequency of human papillomavirus genomes in cervical lesions.人乳头瘤病毒基因组在宫颈病变中的类型依赖性整合频率
Cancer Res. 2008 Jan 1;68(1):307-13. doi: 10.1158/0008-5472.CAN-07-2754.
7
Identification of human papillomavirus (HPV) 16 DNA integration and the ensuing patterns of methylation in HPV-associated head and neck squamous cell carcinoma cell lines.人乳头瘤病毒（HPV）16型DNA整合及HPV相关头颈部鳞状细胞癌细胞系中随之出现的甲基化模式的鉴定。
Int J Cancer. 2017 Apr 1;140(7):1571-1580. doi: 10.1002/ijc.30589. Epub 2017 Jan 9.
8
Interferon treatment of human keratinocytes harboring extrachromosomal, persistent HPV-16 plasmid genomes induces de novo viral integration.干扰素治疗携带额外染色体、持续性 HPV-16 质粒基因组的人角质形成细胞会诱导新的病毒整合。
Carcinogenesis. 2015 Jan;36(1):151-9. doi: 10.1093/carcin/bgu236. Epub 2014 Nov 21.
9
Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.人乳头瘤病毒16型整合入人类基因组与细胞的选择性生长优势相关。
J Virol. 1995 May;69(5):2989-97. doi: 10.1128/JVI.69.5.2989-2997.1995.
10
Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer.人乳头瘤病毒整合与头颈部癌症中的全基因组不稳定性严格相关。
Mol Cancer Res. 2022 Sep 2;20(9):1420-1428. doi: 10.1158/1541-7786.MCR-21-0831.
引用本文的文献
1
Human papillomavirus infection and screening strategies.人乳头瘤病毒感染与筛查策略
World J Clin Oncol. 2025 May 24;16(5):105055. doi: 10.5306/wjco.v16.i5.105055.
2
The viral landscape in metastatic solid cancers.转移性实体癌中的病毒格局。
Heliyon. 2025 Feb 8;11(4):e42548. doi: 10.1016/j.heliyon.2025.e42548. eCollection 2025 Feb 28.
3
Risk of residual/recurrent cervical diseases in HPV-positive women post-conization depends on HPV integration status.锥切术后HPV阳性女性残留/复发性宫颈疾病的风险取决于HPV整合状态。
Infect Agent Cancer. 2025 Jan 28;20(1):5. doi: 10.1186/s13027-025-00637-3.
4
Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use.人乳头瘤病毒在癌症中的作用：致癌机制与临床应用
Signal Transduct Target Ther. 2025 Jan 24;10(1):44. doi: 10.1038/s41392-024-02083-w.
5
Fibroblasts regulate the transcriptional signature of human papillomavirus-positive keratinocytes.成纤维细胞调节人乳头瘤病毒阳性角质形成细胞的转录特征。
Tumour Virus Res. 2024 Dec 10;19:200302. doi: 10.1016/j.tvr.2024.200302.
本文引用的文献
1
Intratumoral Heterogeneity and Clonal Evolution Induced by HPV Integration.HPV 整合诱导的肿瘤内异质性和克隆进化。
Cancer Discov. 2023 Apr 3;13(4):910-927. doi: 10.1158/2159-8290.CD-22-0900.
2
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer.长读测序揭示了宫颈癌中 HPV 整合的高分辨率及其致癌进展。
Nat Commun. 2022 May 10;13(1):2563. doi: 10.1038/s41467-022-30190-1.
3
Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.HPV 介导的口咽癌中的染色体外 DNA 驱动多种癌基因转录。
Clin Cancer Res. 2021 Dec 15;27(24):6772-6786. doi: 10.1158/1078-0432.CCR-21-2484. Epub 2021 Sep 21.
4
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.染色体外 DNA 与多种癌症中的癌基因扩增和不良预后相关。
Nat Genet. 2020 Sep;52(9):891-897. doi: 10.1038/s41588-020-0678-2. Epub 2020 Aug 17.
5
The role of integration in oncogenic progression of HPV-associated cancers.整合在人乳头瘤病毒相关癌症致癌进展中的作用。
PLoS Pathog. 2017 Apr 6;13(4):e1006211. doi: 10.1371/journal.ppat.1006211. eCollection 2017 Apr.
6
Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell carcinoma.对癌症基因组图谱测序数据的分析揭示了人乳头瘤病毒16型基因组在头颈部鳞状细胞癌中的新特性。
Oncotarget. 2017 Mar 14;8(11):17684-17699. doi: 10.18632/oncotarget.15179.
7
Characterization of HPV and host genome interactions in primary head and neck cancers.原发性头颈癌中HPV与宿主基因组相互作用的特征分析
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15544-9. doi: 10.1073/pnas.1416074111. Epub 2014 Oct 13.
8
Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.高危型人乳头瘤病毒感染细胞中基因组不稳定的机制。
PLoS Pathog. 2009 Apr;5(4):e1000397. doi: 10.1371/journal.ppat.1000397. Epub 2009 Apr 24.
Zotero 插件