Laboratory of Viral Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Cancer Discov. 2023 Apr 3;13(4):814-816. doi: 10.1158/2159-8290.CD-23-0097.
Human papillomavirus (HPV)-positive cancer cells contain virus and host DNA and exhibit marked genome instability. In this issue of Cancer Discovery, Akagi and colleagues characterize the remarkably complex landscape of virus-host DNA molecules in HPV-positive cells, providing evidence for diverse integrated and extrachromosomal virus-host hybrid DNAs with the potential to drive clonal evolution. See related article by Akagi et al., p. 910 (4).
人乳头瘤病毒（HPV）阳性癌细胞含有病毒和宿主 DNA，并表现出明显的基因组不稳定性。在本期《癌症发现》中，赤木和同事们描绘了 HPV 阳性细胞中病毒-宿主 DNA 分子的惊人复杂景观，为具有潜在驱动克隆进化能力的多种整合和染色体外病毒-宿主杂交 DNA 提供了证据。见 Akagi 等人的相关文章，第 910 页（4）。
