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The role of integration in oncogenic progression of HPV-associated cancers.

作者信息

McBride Alison A, Warburton Alix

机构信息

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

出版信息

PLoS Pathog. 2017 Apr 6;13(4):e1006211. doi: 10.1371/journal.ppat.1006211. eCollection 2017 Apr.

DOI:10.1371/journal.ppat.1006211
PMID:28384274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5383336/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51e/5383336/8eaf897fed0b/ppat.1006211.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51e/5383336/6e3af71b4375/ppat.1006211.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51e/5383336/8eaf897fed0b/ppat.1006211.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51e/5383336/6e3af71b4375/ppat.1006211.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51e/5383336/8eaf897fed0b/ppat.1006211.g002.jpg

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本文引用的文献

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2
Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.常见脆性位点（CFS）和极大的CFS基因是口咽鳞状细胞癌中人乳头瘤病毒整合和染色体重排的靶点。
Genes Chromosomes Cancer. 2017 Jan;56(1):59-74. doi: 10.1002/gcc.22415. Epub 2016 Nov 1.
3
Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral Oncogenes.
基于可扩展长读长纳米孔HPV16扩增子的全基因组测序
medRxiv. 2025 May 23:2025.05.22.25328149. doi: 10.1101/2025.05.22.25328149.
4
Molecular Mechanisms and Clinical Divergences in HPV-Positive Cervical vs. Oropharyngeal Cancers: A Critical Narrative Review.人乳头瘤病毒阳性宫颈癌与口咽癌的分子机制及临床差异：一篇批判性叙述综述
BMC Med. 2025 Jul 7;23(1):405. doi: 10.1186/s12916-025-04247-z.
5
Human Papillomavirus Genomes Associate with Active Host Chromatin during Persistent Viral Infection.在持续性病毒感染期间，人乳头瘤病毒基因组与活跃的宿主染色质相关联。
bioRxiv. 2025 Apr 17:2025.04.15.649012. doi: 10.1101/2025.04.15.649012.
6
Applications for Circulating Cell-Free DNA in Oral Squamous Cell Carcinoma: A Non-Invasive Approach for Detecting Structural Variants, Fusions, and Oncoviruses.循环游离DNA在口腔鳞状细胞癌中的应用：一种检测结构变异、融合和肿瘤病毒的非侵入性方法。
Cancers (Basel). 2025 Jun 6;17(12):1901. doi: 10.3390/cancers17121901.
7
Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC.利用CRISPR-SONIC构建具有位点特异性癌基因插入的自发性小鼠HPV阳性口腔癌模型。
Cell Biosci. 2025 Jun 18;15(1):84. doi: 10.1186/s13578-025-01427-5.
8
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Cancers (Basel). 2025 May 22;17(11):1740. doi: 10.3390/cancers17111740.
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Nat Commun. 2025 Jun 11;16(1):5285. doi: 10.1038/s41467-025-59409-7.
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Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay.通过靶向RNA下一代测序分析对人高危型人乳头瘤病毒（hrHPV）诱导的宫颈高级别鳞状上皮内病变进行分子检测。
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Int J Cancer. 2016 Jan 15;138(2):386-95. doi: 10.1002/ijc.29712. Epub 2015 Aug 13.
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J Med Virol. 2015 Jun;87(6):1022-33. doi: 10.1002/jmv.24129. Epub 2015 Feb 3.