Department of Health Management, Daping Hospital, Army Medical University, Chongqing, 400010, China.
Department of Otolaryngology Head and Neck Surgery, Daping Hospital, Army Medical University, Chongqing, 400010, China.
BMC Mol Cell Biol. 2023 Apr 3;24(1):15. doi: 10.1186/s12860-023-00477-2.
Nasopharyngeal carcinoma is a tumor with high malignancy and poor prognosis, which severely affects the health of the patients. LncRNAs and microRNAs are crucial for the occurrence and development of nasopharyngeal carcinoma, which regulate the progression of nasopharyngeal carcinoma through the ceRNA network. SCARB1 plays an essential role in nasopharyngeal carcinoma. However, the mechanism underlying the regulation of SCARB1 in nasopharyngeal carcinoma through non-coding RNAs remains unclear. Our findings indicated that the SCAT8/miR-125b-5p axis promoted the malignant progression of nasopharyngeal carcinoma by driving the expression of SCARB1. Mechanistically, the expression of SCARB1 could be regulated by the lncRNA, SCAT8 and the microRNA, miR-125b-5p. Moreover, as a ceRNA of miR-125b-5p, SCAT8 can not only regulate the expression of SCARB1, but also regulate the malignant progression of nasopharyngeal carcinoma. Notably, our results reveal a novel ceRNA regulatory network in nasopharyngeal carcinoma, which could serve as a potential target for the diagnosis and treatment of nasopharyngeal carcinoma.
鼻咽癌是一种恶性程度高、预后差的肿瘤，严重影响患者的健康。lncRNAs 和 microRNAs 对鼻咽癌的发生发展至关重要，它们通过 ceRNA 网络调节鼻咽癌的进展。SCARB1 在鼻咽癌中发挥着重要作用。然而，非编码 RNA 调控 SCARB1 在鼻咽癌中的机制尚不清楚。我们的研究结果表明，SCAT8/miR-125b-5p 轴通过驱动 SCARB1 的表达促进鼻咽癌的恶性进展。在机制上，SCARB1 的表达可以通过 lncRNA、SCAT8 和 microRNA miR-125b-5p 来调节。此外，作为 miR-125b-5p 的 ceRNA，SCAT8 不仅可以调节 SCARB1 的表达，还可以调节鼻咽癌的恶性进展。值得注意的是，我们的研究结果揭示了鼻咽癌中一种新的 ceRNA 调控网络，可为鼻咽癌的诊断和治疗提供潜在靶点。
