Hall S, Czaja A J, Kaufman D K, Markowitz H, Ginsburg W W
J Rheumatol. 1986 Feb;13(1):95-8.
The records of 89 patients with hepatitis B surface antigen, negative severe chronic active hepatitis and antinuclear antibody (ANA) positivity were reviewed to assess the degree of clinical similarity between this disorder and systemic lupus erythematosus (SLE). Although immunologic abnormalities, such as antibodies to native DNA and positive lupus erythematosus cell preparations were common, few patients with ANA positive chronic active hepatitis had clinical features to suggest SLE. The 1971 preliminary criteria and the 1982 revision of the American Rheumatism Association criteria for classification of SLE were 93 and 91% specific, respectively. We conclude that despite laboratory similarities, ANA positive chronic active hepatitis and SLE differ substantially in their clinical presentations.
回顾了89例乙肝表面抗原阴性的重度慢性活动性肝炎且抗核抗体（ANA）阳性患者的记录，以评估该疾病与系统性红斑狼疮（SLE）之间的临床相似程度。尽管存在免疫异常，如抗天然DNA抗体和狼疮细胞检查阳性很常见，但很少有ANA阳性的慢性活动性肝炎患者具有提示SLE的临床特征。美国风湿病协会1971年的SLE初步分类标准和1982年的修订标准的特异性分别为93%和91%。我们得出结论，尽管在实验室检查方面存在相似之处，但ANA阳性的慢性活动性肝炎和SLE在临床表现上有很大差异。
