Department of Microbiology, Kanya Gurukul Campus, Gurukul Kangri University, Haridwar, 249407, India.
Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India.
Arch Microbiol. 2023 Apr 5;205(5):172. doi: 10.1007/s00203-023-03499-8.
Bioplastics replace synthetic plastics of petrochemical origin, which contributes challenge to both polymer quality and economics. Novel polyhydroxyalkanoates (PHA)-composite materials, with desirable product quality, could be developed, thus targeting the global plastics market, in the coming years. It is possible that PHA can be a greener substitute for their petroleum-based competitors since they are simply decomposed, which may lessen the pressure on municipal and industrial waste management systems. PHA production has proven to be the bottleneck in industrial application and commercialization because of the high price of carbon substrates and downstream processes required to achieve reliability. Bacterial PHA production by these municipal and industrial wastes, which act as a cheap, renewable carbon substrate, eliminates waste management hassles and acts as an efficient substitute for synthetic plastics. In the present review, challenges and opportunities related to the commercialization of polyhydroxyalkanoates are discussed and presented. Moreover, it discusses critical steps of their production process, feedstock evaluation, optimization strategies, and downstream processes. This information may provide us the complete utilization of bacterial PHA during possible applications in packaging, nutrition, medicine, and pharmaceuticals.
生物塑料替代了源自石化的合成塑料，这给聚合物质量和经济性带来了挑战。在未来几年，有可能开发出具有理想产品质量的新型聚羟基烷酸酯 (PHA)-复合材料，从而瞄准全球塑料市场。PHA 可以作为其石油基竞争对手的更环保替代品，因为它们可以简单地分解，这可能会减轻城市和工业废物管理系统的压力。由于碳底物的高价格和实现可靠性所需的下游工艺，PHA 的生产已被证明是工业应用和商业化的瓶颈。这些城市和工业废物作为廉价、可再生的碳底物来生产细菌 PHA，可以消除废物管理的麻烦，并且是合成塑料的有效替代品。在本综述中，讨论并介绍了与聚羟基烷酸酯商业化相关的挑战和机遇。此外，还讨论了它们生产过程、原料评估、优化策略和下游工艺的关键步骤。这些信息可能为我们在包装、营养、医药和制药等可能的应用中充分利用细菌 PHA 提供了依据。
