Kapur M M, Jain P, Gidh M
J Trauma. 1986 May;26(5):464-6. doi: 10.1097/00005373-198605000-00010.
The sera of 12 patients with mechanical trauma were studied to determine C3 levels and activation. The injury severity score (ISS) was then related to serum C3 levels and activation. It was found that in the immediate postinjury period, serum C3 activation occurred in cases where ISS was greater than or equal to 12. The mean ISS of patients with complement activation was 25.2. In comparison, in patients with nonactivation of complement, the mean ISS was 9.5 (p less than 0.05). Serum C3 levels were inversely related to ISS. The mean serum C3 level of patients with ISS greater than or equal to 12 was 73.3 mg% and mean serum C3 level with ISS less than 12 was 109.4 mg%. This difference was again statistically significant (p less than 0.05). There is indication that complement depletion occurs in the immediate postinjury period in moderate to severe injury (ISS greater than or equal to 12). This finding could explain, in part, the immunosuppressive effect of trauma and can be used as a marker to predict possible septic complications.
对12例机械性创伤患者的血清进行研究，以测定C3水平及活化情况。然后将损伤严重程度评分（ISS）与血清C3水平及活化情况相关联。结果发现，在伤后即刻，ISS大于或等于12的病例出现血清C3活化。补体活化患者的平均ISS为25.2。相比之下，补体未活化患者的平均ISS为9.5（p<0.05）。血清C3水平与ISS呈负相关。ISS大于或等于12的患者血清C3平均水平为73.3mg%，ISS小于12的患者血清C3平均水平为109.4mg%。这种差异同样具有统计学意义（p<0.05）。有迹象表明，在中度至重度损伤（ISS大于或等于12）的伤后即刻会发生补体耗竭。这一发现可以部分解释创伤的免疫抑制作用，并可作为预测可能发生脓毒症并发症的一个指标。
