Brown N A, Liu C, Garcia C R, Wang Y F, Griffith A, Sparkes R S, Calame K L
J Virol. 1986 Jun;58(3):975-8. doi: 10.1128/JVI.58.3.975-978.1986.
Analysis of immunoglobulin gene rearrangements in 16 B-cell lineages clonally propagated from two mononucleosis patients supported the notion that mononucleosis is a polyclonal B-lymphoproliferative disorder. Three of seven cell clones from a patient with a fatal B lymphoma revealed the same pattern of immunoglobulin gene rearrangement, indicating that this patient's disease was oligoclonal. The three similar clones were propagated from two sites (blood and spleen), indicating that they represent a metastatic cell lineage which arose during the patient's fatal B lymphoproliferation.
对两名单核细胞增多症患者克隆增殖的16个B细胞谱系中的免疫球蛋白基因重排进行分析，支持了单核细胞增多症是一种多克隆B淋巴细胞增殖性疾病的观点。一名患有致命性B淋巴瘤患者的七个细胞克隆中有三个显示出相同的免疫球蛋白基因重排模式，表明该患者的疾病是寡克隆性的。这三个相似的克隆是从两个部位（血液和脾脏）增殖而来的，表明它们代表了在患者致命性B淋巴细胞增殖过程中出现的一个转移细胞谱系。
