鼻咽癌中重排的爱泼斯坦-巴尔病毒基因组及克隆起源
Rearranged Epstein-Barr virus genomes and clonal origin in nasopharyngeal carcinoma.
作者信息
Shimakage M, Chatani M, Ikegami N, Hirai K
机构信息
Clinical Research Institute, Osaka National Hospital.
出版信息
Jpn J Cancer Res. 1989 Jul;80(7):612-6. doi: 10.1111/j.1349-7006.1989.tb01685.x.
Epstein-Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NPC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single-sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV-infected cell.
已知爱泼斯坦-巴尔病毒（EBV）与两种恶性疾病相关，即鼻咽癌（NPC）和地方性伯基特淋巴瘤。在本研究中，使用Southern印迹杂交分析了来自日本4例NPC患者活检标本中EBV的基因组。所有检查病例的NPC组织均含有重排的EBV基因组，其BamHI H片段比原型EBV基因组的片段大。其中一个含有包含BamHI Y和H连续序列的BamHI片段。在这些NPC组织中观察到单一大小的EBV DNA末端，这意味着癌是由单个EBV感染细胞演变而来的。
Zotero 插件