On the parameter estimation of Box-Cox transformation cure model.

We propose an improved estimation method for the Box-Cox transformation (BCT) cure rate model parameters. Specifically, we propose a generic maximum likelihood estimation algorithm through a non-linear conjugate gradient (NCG) method with an efficient line search technique. We then apply the proposed NCG algorithm to BCT cure model. Through a detailed simulation study, we compare the model fitting results of the NCG algorithm with those obtained by the existing expectation maximization (EM) algorithm. First, we show that our proposed NCG algorithm allows simultaneous maximization of all model parameters unlike the EM algorithm when the likelihood surface is flat with respect to the BCT index parameter. Then, we show that the NCG algorithm results in smaller bias and noticeably smaller root mean square error of the estimates of the model parameters that are associated with the cure rate. This results in more accurate and precise inference on the cure rate. In addition, we show that when the sample size is large the NCG algorithm, which only needs the computation of the gradient and not the Hessian, takes less CPU time to produce the estimates. These advantages of the NCG algorithm allows us to conclude that the NCG method should be the preferred estimation method over the already existing EM algorithm in the context of BCT cure model. Finally, we apply the NCG algorithm to analyze a well-known melanoma data and show that it results in a better fit when compared to the EM algorithm.