Saad Norma, Duroux-Richard Isabelle, Touitou Isabelle, Jeziorski Eric, Apparailly Florence
Institute for Regenerative Medicine and Biotherapy, INSERM, U1183, University of Montpellier, Montpellier, France.
Institute for Regenerative Medicine and Biotherapy, INSERM, U1183, University of Montpellier, Montpellier, France; Department of Molecular genetics, Medical Genetics of Rare and Autoinflammatory disease unit, Montpellier University Hospital, Montpellier, France; Centre de référence des maladies autoinflammatoires et des amyloses d'origine inflammatoire, CeRéMAIA, Montpellier University Hospital, Montpellier, France.
Immunol Lett. 2023 Apr-May;256-257:48-54. doi: 10.1016/j.imlet.2023.04.001. Epub 2023 Apr 5.
microRNAs (miRNAs) are small non-coding RNA sequences that negatively regulate the expression of protein-encoding genes at the post-transcriptional level. They play a role in the regulation of inflammatory responses by controlling the proliferation and activation of immune cells and their expression is disrupted in several immune-mediated inflammatory disorders. Among these, autoinflammatory diseases (AID) are a group of rare hereditary disorders caused by abnormal activation of the innate immune system and characterized by recurrent fevers. Major groups of AID are inflammasomopathies, which are associated with hereditary defects in the activation of inflammasomes, cytosolic multiprotein signaling complexes regulating IL-1 family cytokine maturation and pyroptosis. The study of the role of miRNAs in AID is only recently emerging and remains scarce in inflammasomopathies. In this review, we describe the AID and inflammasomopathies, and the current knowledge on the role of miRNAs in disease processes.
微小RNA（miRNA）是小的非编码RNA序列，它们在转录后水平上负向调节蛋白质编码基因的表达。它们通过控制免疫细胞的增殖和活化在炎症反应调节中发挥作用，并且其表达在几种免疫介导的炎症性疾病中受到破坏。其中，自身炎症性疾病（AID）是一组由先天免疫系统异常激活引起的罕见遗传性疾病，其特征为反复发热。AID的主要类型是炎性小体病，它与炎性小体激活的遗传性缺陷有关，炎性小体是调节IL-1家族细胞因子成熟和细胞焦亡的胞质多蛋白信号复合物。miRNA在AID中的作用研究最近才刚刚兴起，在炎性小体病方面仍然很少。在这篇综述中，我们描述了AID和炎性小体病，以及目前关于miRNA在疾病过程中作用的知识。
