用于治疗应用的工程抗真菌肽的策略和机会。
Strategies and opportunities for engineering antifungal peptides for therapeutic applications.
机构信息
Department of Chemical and Biomolecular Engineering, University of Maryland, 2113 Chemical and Nuclear Engineering Building (#090), 4418 Stadium Drive, College Park, MD 20742, USA.
Department of Chemical and Biomolecular Engineering, University of Maryland, 2113 Chemical and Nuclear Engineering Building (#090), 4418 Stadium Drive, College Park, MD 20742, USA.
出版信息
Curr Opin Biotechnol. 2023 Jun;81:102926. doi: 10.1016/j.copbio.2023.102926. Epub 2023 Apr 5.
Antifungal peptides (AFPs) are widely described as promising prospects to treat and prevent fungal infections, though they are far less studied than their antibacterial counterparts. Although promising, AFPs have practical limitations that have hindered their use as therapeutics. Rational design and combinatorial engineering are powerful protein engineering strategies with much potential to address the limitations of AFPs by designing peptides with improved physiochemical and biological characteristics. We examine how rational design and combinatorial engineering approaches have already been used to improve the properties of AFPs and propose key opportunities for applying these strategies to push the design and application of AFPs forward.
抗菌肽（AFPs）被广泛描述为治疗和预防真菌感染的有前途的方法，尽管它们的研究远不及抗菌肽广泛。尽管有前景，但 AFPs 存在实际限制，这阻碍了它们作为治疗剂的应用。理性设计和组合工程是强大的蛋白质工程策略，具有很大的潜力通过设计具有改进的物理化学和生物学特性的肽来解决 AFPs 的局限性。我们研究了理性设计和组合工程方法如何已经被用于改善 AFPs 的性质，并提出了应用这些策略的关键机会，以推动 AFPs 的设计和应用。
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