Patchell R A, Posner J B
Neurology. 1986 Jun;36(6):745-9. doi: 10.1212/wnl.36.6.745.
We reviewed the records of all patients treated for carcinoid tumors at Memorial Sloan-Kettering Cancer Center from 1974 through 1984. Of 219 patients, 90 developed metastatic complications, and of these, 36 developed neurologic complications. Metastases, the most common neurologic complication, included epidural spinal cord compression (14 patients), intracranial metastases (13 patients), leptomeningeal metastases (1 patient), and peripheral nerve lesions (5 patients). Nonmetastatic complications were hepatic encephalopathy (six patients), herpes zoster infection (two patients), cerebral infarction due to septic emboli (one patient), superior sagittal sinus thrombosis (one patient), and carcinoid myopathy (one patient). The carcinoid syndrome was seen in eight patients (4%). Response of neurologic metastases to conventional radiation therapy was usually favorable. We conclude that (1) the frequency and type of neurologic complications associated with carcinoid tumors are similar to those seen with other systemic cancers; (2) CNS metastases are relatively common in patients with metastatic carcinoid (29%); and (3) the carcinoid syndrome is less common than CNS metastasis.
我们回顾了1974年至1984年在纪念斯隆-凯特琳癌症中心接受类癌肿瘤治疗的所有患者的记录。在219名患者中，90名出现了转移并发症，其中36名出现了神经并发症。转移是最常见的神经并发症，包括硬膜外脊髓压迫（14例患者）、颅内转移（13例患者）、软脑膜转移（1例患者）和周围神经病变（5例患者）。非转移性并发症包括肝性脑病（6例患者）、带状疱疹感染（2例患者）、脓毒性栓子导致的脑梗死（1例患者）、上矢状窦血栓形成（1例患者）和类癌性肌病（1例患者）。8名患者（4%）出现类癌综合征。神经转移对传统放射治疗的反应通常较好。我们得出结论：（1）与类癌肿瘤相关的神经并发症的频率和类型与其他全身性癌症所见相似；（2）中枢神经系统转移在转移性类癌患者中相对常见（29%）；（3）类癌综合征比中枢神经系统转移少见。
