Wang Wei, Guan Fengtao, Sagratini Gianni, Yan Jie, Xie Jiahan, Jin Zhibo, Liu Meihong, Liu Huimin, Liu Jingsheng
College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
College of Life Science, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Curr Res Food Sci. 2023 Mar 21;6:100491. doi: 10.1016/j.crfs.2023.100491. eCollection 2023.
Ginsenoside Rd is a protopanaxadiol abundant in Panax ginseng and Panax notoginseng. It has been reported that ginsenoside Rd possesses various health benefits, such as anti-diabetic, anti-tumor and anti-inflammatory. This work explored the effects of ginsenoside Rd on hyperglycemia and gut microbiota in streptozotocin-induced diabetic rats. Results showed that 5-week ginsenoside Rd (20 mg/kg) treatment significantly improved hyperglycemia in diabetic rats. Besides, ginsenoside Rd promoted glycogen synthesis via activating Akt pathway. It also inhibited hepatic gluconeogenesis, which was associated with inhibiting phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. We further found that ginsenoside Rd treatment increased the diversity of gut microbiota, increased the abundance of beneficial bacteria, such as , and , and reduced the abundance of conditional pathogenic bacteria. These results indicated that ginsenoside Rd has the potential for diabetic intervention.
人参皂苷Rd是一种在人参和三七中含量丰富的原人参二醇。据报道，人参皂苷Rd具有多种健康益处，如抗糖尿病、抗肿瘤和抗炎作用。本研究探讨了人参皂苷Rd对链脲佐菌素诱导的糖尿病大鼠高血糖和肠道微生物群的影响。结果表明，连续5周给予人参皂苷Rd（20mg/kg）可显著改善糖尿病大鼠的高血糖症状。此外，人参皂苷Rd通过激活Akt信号通路促进糖原合成。它还抑制肝脏糖异生，这与抑制磷酸烯醇式丙酮酸羧激酶和葡萄糖-6-磷酸酶有关。我们进一步发现，人参皂苷Rd治疗可增加肠道微生物群的多样性，增加有益菌如、和的丰度，并降低条件致病菌的丰度。这些结果表明人参皂苷Rd具有糖尿病干预的潜力。
