Kar Bikash Ranjan, Singh Bhabani S T P, Agrawal Ishan
Department of Dermatology, IMS and SUM Hospital, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
J Cutan Aesthet Surg. 2022 Oct-Dec;15(4):355-362. doi: 10.4103/JCAS.JCAS_10_22.
Vitiligo is a common autoimmune depigmentary disorder seen among Indian patients. It has a significant impact on the self-esteem of the patient. Specific sites including acral areas, joints, and lips are usually resistant to medical therapy and thus transfer of melanocytes is mandatory for the treatment. Vitiligo at the angle of lips is distinct from the vitiligo on other sites, with respect to response to therapy, lack of hair follicles, and high mobility of the area. Our aim was to review the various therapeutic modalities available for the treatment of vitiligo at this site. In our narrative review, we searched databases including PubMed, Google Scholar, and EBSCO with a full strategic search with keywords "Vitiligo," "leucoderma," "mucosal vitiligo," "lips," "labial," "angle of lips," "Minipunch grafting," "Suction Blister epidermal Grafting," "SBEG," "Micropigmentation," "tattooing," and "Excision" from 2005 to 2021. The relevant articles were extracted and included in the review. Various modalities including suction blister grafting, miniature punch grafting, split-thickness grafting, and micropigmentation have been reviewed with their advantages and disadvantages. Various potential modalities of therapy have also been proposed in the review.
白癜风是印度患者中常见的一种自身免疫性色素脱失性疾病。它对患者的自尊有重大影响。包括肢端部位、关节和嘴唇在内的特定部位通常对药物治疗有抵抗性，因此黑素细胞移植是治疗的必要手段。就治疗反应、缺乏毛囊以及该部位的高活动性而言，唇角处的白癜风与其他部位的白癜风不同。我们的目的是回顾可用于治疗该部位白癜风的各种治疗方式。在我们的叙述性综述中，我们检索了包括PubMed、谷歌学术和EBSCO在内的数据库，使用关键词“白癜风”“白斑病”“黏膜白癜风”“嘴唇”“唇部”“唇角”“微小钻孔移植术”“吸疱表皮移植术”“SBEG”“微色素沉着”“纹身”和“切除术”进行了全面的策略性检索，检索时间跨度为2005年至2021年。提取相关文章并纳入综述。对包括吸疱移植术、微小钻孔移植术、断层皮片移植术和微色素沉着在内的各种方式及其优缺点进行了综述。综述中还提出了各种潜在的治疗方式。
