Department of Tea Science , Zhejiang University , Hangzhou , Zhejiang 310058 , People's Republic of China.
Department of Chemical Biology, Ernest Mario School of Pharmacy , Rutgers, The State University of New Jersey , Piscataway , New Jersey 08854 , United States.
J Agric Food Chem. 2019 May 15;67(19):5361-5373. doi: 10.1021/acs.jafc.8b05348. Epub 2019 Jan 22.
During the past 20 years, many studies have focused on polyphenol compounds for their potential beneficial health effects. Flavonoids represent a large class of phenolic compounds found in fruits, vegetables, nuts, grains, cocoa, tea, and other beverages. Flavonoids have shown antioxidant and anti-inflammatory activities. Given the putative relationship between inflammation and insulin resistance, the consumption of flavonoids or flavonoid-rich foods has been suggested to reduce the risk of diabetes by targeting inflammatory signals. This is the first comprehensive review summarizing the current research progress on the inhibition of inflammation and alleviation of insulin resistance by flavonoids as well as the mechanistic link between these disorders. Laboratory and human studies on the activities of major flavonoids (flavones, isoflavones, flavonols, etc.) are discussed.
在过去的 20 年中，许多研究都集中在多酚化合物上，因为它们具有潜在的有益健康的作用。类黄酮是一类存在于水果、蔬菜、坚果、谷物、可可、茶和其他饮料中的酚类化合物。类黄酮具有抗氧化和抗炎活性。鉴于炎症与胰岛素抵抗之间的假定关系，人们认为通过靶向炎症信号，摄入类黄酮或富含类黄酮的食物可以降低患糖尿病的风险。这是第一篇综述，总结了类黄酮抑制炎症和缓解胰岛素抵抗的最新研究进展，以及这些疾病之间的机制联系。讨论了主要类黄酮（黄酮类、异黄酮类、黄酮醇等）的实验室和人体研究。
