美国儿童失明的病因研究——IRIS® 注册研究（智能视觉研究）。
Causes of Childhood Blindness in the United States Using the IRIS® Registry (Intelligent Research in Sight).
机构信息
Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California; Department of Ophthalmology, Hanyang University School of Medicine, Seoul, Republic of Korea.
Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California; Ophthalmology and Eye Care Services, VA Palo Alto Health Care System, Palo Alto, California.
出版信息
Ophthalmology. 2023 Sep;130(9):907-913. doi: 10.1016/j.ophtha.2023.04.004. Epub 2023 Apr 8.
PURPOSE
To investigate causes of childhood blindness in the United States using the IRIS® Registry (Intelligent Research in Sight).
DESIGN
Cross-sectional study.
PARTICIPANTS
Patients ≤ 18 years of age with visual acuity (VA) 20/200 or worse in their better-seeing eye in the IRIS Registry during 2018.
METHODS
Causes of blindness were classified by anatomic site and specific diagnoses.
MAIN OUTCOME MEASURES
Percentages of causes of blindness.
RESULTS
Of 81 164 children with 2018 VA data in the IRIS Registry, 961 (1.18%) had VA 20/200 or worse in their better-seeing eye. Leading causes of blindness were retinopathy of prematurity (ROP) in 301 patients (31.3%), nystagmus in 78 patients (8.1%), and cataract in 64 patients (6.7%). The retina was the leading anatomic site (47.7%) followed by optic nerve (11.6%) and lens (10.0%). A total of 52.4% of patients had treatable causes of blindness.
CONCLUSIONS
This analysis offers a unique cross-sectional view of childhood blindness in the United States using a clinical data registry. More than one-half of blind patients had a treatable cause of blindness.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
目的
利用智能研究视觉（IRIS®）登记处调查美国儿童失明的原因。
设计
横断面研究。
参与者
在 2018 年的 IRIS 登记处中，视力（VA）≥20/200 的≤18 岁患者，其较好眼的 VA 更差。
方法
通过解剖部位和特定诊断对失明原因进行分类。
主要观察指标
失明原因的百分比。
结果
在 81164 名具有 2018 年 VA 数据的儿童中，961 名（1.18%）其较好眼的 VA 为 20/200 或更差。失明的主要原因是早产儿视网膜病变（ROP）301 例（31.3%）、眼球震颤 78 例（8.1%）和白内障 64 例（6.7%）。视网膜是主要的解剖部位（47.7%），其次是视神经（11.6%）和晶状体（10.0%）。共有 52.4%的患者有可治疗的失明原因。
结论
本分析利用临床数据登记处提供了美国儿童失明的独特横断面视图。超过一半的盲童有可治疗的失明原因。
金融披露
本文结尾的脚注和披露中可能有专有或商业披露。
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