Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia.
Institute of Human Virology, Abuja, Nigeria.
Am J Trop Med Hyg. 2023 Apr 10;108(5):977-980. doi: 10.4269/ajtmh.22-0670. Print 2023 May 3.
Yaws is a chronic, relapsing disease of skin, bone, and cartilage caused by Treponema pallidum subsp. pertenue. Yaws was last reported in Nigeria in 1996, although neighboring countries have recently reported cases. We investigated serological evidence for yaws among children aged 0-14 years in Nigeria by measuring antibodies to the treponemal antigens rp17 and TmpA in blood specimens from a 2018 nationally representative HIV survey using a multiplex bead assay. The presence of antibodies to both antigens ("double positive") likely reflects current or recent treponemal infection. Overall, 1.9% (610/31,549) of children had anti-TmpA antibodies, 1.5% (476/31,549) had anti-rp17 antibodies, and 0.1% (39/31,549) were double positive. Among households, 0.5% (84/18,021) had a double-positive child, with a clustering of double-positive children. Although numbers are low, identification of antibodies to both TmpA and rp17 may warrant investigation, including more granular epidemiologic and clinical data, to assess the potential for continuing yaws transmission in Nigerian children.
雅司病是一种由苍白密螺旋体亚种地方性亚种引起的慢性、复发性皮肤、骨骼和软骨疾病。尼日利亚最后一次报告雅司病是在 1996 年，尽管邻国最近也报告了病例。我们通过使用多重微珠检测法在 2018 年全国代表性艾滋病毒调查的血液样本中测量针对梅毒螺旋体抗原 rp17 和TmpA 的抗体，调查了尼日利亚 0-14 岁儿童中雅司病的血清学证据。两种抗原的抗体均存在（“双阳性”）可能反映了当前或近期的梅毒螺旋体感染。总体而言，1.9%（610/31549）的儿童有抗-TmpA 抗体，1.5%（476/31549）有抗-rp17 抗体，0.1%（39/31549）为双阳性。在家庭中，0.5%（84/18021）有一个双阳性儿童，存在双阳性儿童聚集的情况。尽管数量较低，但识别出对 TmpA 和 rp17 的抗体可能需要进行调查，包括更详细的流行病学和临床数据，以评估雅司病在尼日利亚儿童中持续传播的可能性。
