Mao Liwei, Wang Lian, Xu Jiake, Zou Jun
School of Kinesiology, Shanghai University of Sport, 200438, Shanghai, China.
School of Biomedical Sciences, The University of Western Australia, WA, 6009, Perth, Australia.
Cell Death Discov. 2023 Apr 10;9(1):119. doi: 10.1038/s41420-023-01417-x.
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in the regulation of bone metabolism of bone precursor cells, mesenchymal stem cells (MSCs), osteoblasts (OBs), osteoclasts (OCs), and osteocytes. Recent studies expanded and updated the role of integrin in bone metabolism, and a large number of novel cytokines were found to activate bone metabolism pathways through interaction with integrin receptors. Integrins act as transducers that mediate the regulation of bone-related cells by mechanical stress, fluid shear stress (FSS), microgravity, hypergravity, extracellular pressure, and a variety of physical factors. Integrins mediate bone metastasis of breast, prostate, and lung cancer by promoting cancer cell adhesion, migration, and survival. Integrin-mediated targeted therapy showed promising prospects in bone metabolic diseases. This review emphasizes the latest research results of integrins in bone metabolism and bone metastasis and provides a vision for treatment strategies.
整合素一直是细胞-细胞外基质黏附（ECM）和细胞因子受体信号转导的研究重点。它们参与调节骨前体细胞、间充质干细胞（MSCs）、成骨细胞（OBs）、破骨细胞（OCs）和骨细胞的骨代谢。最近的研究扩展并更新了整合素在骨代谢中的作用，发现大量新型细胞因子通过与整合素受体相互作用激活骨代谢途径。整合素作为传感器，介导机械应力、流体剪切应力（FSS）、微重力、超重力、细胞外压力和多种物理因素对骨相关细胞的调节。整合素通过促进癌细胞黏附、迁移和存活来介导乳腺癌、前列腺癌和肺癌的骨转移。整合素介导的靶向治疗在骨代谢疾病中显示出有前景的前景。本综述强调了整合素在骨代谢和骨转移方面的最新研究成果，并为治疗策略提供了展望。
