Nettelblad H, Randolph M A, Weiland A J
Plast Reconstr Surg. 1986 May;77(5):814-20. doi: 10.1097/00006534-198605000-00021.
The reconstructive potential of microvascular transplantation of skeletal growth plates was investigated through heterotopic transfers. The distal radius was resected in two series of puppies of a known large breed and substituted with a microsurgically revascularized transplant from the proximal fibula. Evaluation was conducted through serial roentgenograms, goniometric registration of joint mobility, volume measurements, histology, and fluorescent bone labeling. In the first series, development of neuropathic-like destruction of the weight-bearing graft ensued in the majority of the animals. In the second series, prolonged protection from weight bearing inhibited this destruction and resulted in hypertrophy of the revascularized epiphyseal end of the transplant but clearly reduced longitudinal growth, with only one transplant exhibiting longitudinal growth that exceeded 50 percent of the value for the control. This experiment demonstrates that skeletal growth plates possess a capacity for hypertrophy under the influence of increased loads. Whether this adaptability is sufficient to allow microvascular transplantation of growth plates to become a clinically useful procedure in children remains unclear. Further laboratory investigations are mandatory prior to clinical application of microvascular transfers of epiphyseal growth plates.
通过异位移植研究了骨骼生长板微血管移植的重建潜力。在两个已知大型犬种的幼犬系列中切除桡骨远端，并用来自腓骨近端的显微外科再血管化移植进行替代。通过系列X线片、关节活动度的角度测量记录、体积测量、组织学和荧光骨标记进行评估。在第一组中，大多数动物的负重移植物出现了类似神经性的破坏。在第二组中，长期避免负重抑制了这种破坏，并导致移植再血管化骨骺端肥大，但明显降低了纵向生长，只有一个移植物的纵向生长超过对照值的50%。该实验表明，骨骼生长板在负荷增加的影响下具有肥大的能力。这种适应性是否足以使生长板的微血管移植成为儿童临床上有用的手术尚不清楚。在骨骺生长板微血管转移临床应用之前，必须进行进一步的实验室研究。
