Boyer M I, Bray P W, Bowen C V
Division of Surgical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
Br J Plast Surg. 1994 Dec;47(8):563-9. doi: 10.1016/0007-1226(94)90141-4.
Non-vascularized and vascularized transplantation of epiphyseal plate autografts have been performed both clinically and experimentally for over 100 years. However, the ultimate clinical goal of vascularized transplantation of epiphyseal plate allografts for paediatric extremity reconstruction remains elusive, due primarily to the lack of suitably nontoxic techniques to prevent graft rejection. We have summarized the published clinical and experimental investigations of vascularized epiphyseal plate transplantation, and organized the experiments and clinical operations into four main groups: (1) local vascular studies on unmanipulated epiphyseal plates, (2) studies of epiphyseal plate behaviour after orthotopic replantation, (3) studies of epiphyseal plate behaviour after heterotopic transplantation, and (4) studies of epiphyseal plate behaviour after allograft transplantation. Prior investigations into the non-vascularized transplantation of epiphyseal plate autografts and allografts are presented as background. These groups of studies serve as the building blocks for the more clinically applicable experimental investigations outlined in the final section of this review.
骨骺板自体移植的非血管化和血管化移植在临床和实验中都已开展了100多年。然而，骨骺板同种异体血管化移植用于小儿肢体重建的最终临床目标仍难以实现，主要原因是缺乏适当的无毒技术来防止移植物排斥反应。我们总结了已发表的关于血管化骨骺板移植的临床和实验研究，并将实验和临床操作分为四个主要类别：（1）未处理骨骺板的局部血管研究；（2）原位再植后骨骺板行为的研究；（3）异位移植后骨骺板行为的研究；（4）同种异体移植后骨骺板行为的研究。对骨骺板自体移植和同种异体移植的非血管化移植的先前研究作为背景呈现。这些研究类别是本综述最后部分概述的更具临床应用价值的实验研究的基础。
