Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Cell Biology & Physiology, University of Kansas Medical Center, Kansas City, KS 66103, USA.
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Curr Biol. 2023 Apr 10;33(7):R255-R256. doi: 10.1016/j.cub.2023.02.036.
It has become clear that circadian clocks in peripheral tissues play important functions. Disruption of the circadian clock in skeletal muscle, for example, results in insulin resistance, sarcomere disorganization, and muscle weakness. Interestingly, cavefish, which exhibit a disrupted central clock, exhibit similar muscle phenotypes, raising the question of whether they are caused by alterations to central or peripheral clocks. Here, we demonstrate a loss in clock function in the skeletal muscle of the Mexican Cavefish Astyanax mexicanus that is associated with reduced rhythmicity of a large number of genes and disrupted nocturnal protein catabolism. Some of the identified genes are associated with metabolic dysfunction in humans.
现已清楚的是，外周组织中的生物钟发挥着重要作用。例如，骨骼肌生物钟的破坏会导致胰岛素抵抗、肌节紊乱和肌肉无力。有趣的是，表现出中央时钟破坏的洞穴鱼也表现出类似的肌肉表型，这就提出了一个问题，即这些表型是由中央时钟还是外周时钟的改变引起的。在这里，我们证明了墨西哥洞穴鱼 Astyanax mexicanus 骨骼肌中的生物钟功能丧失，这与大量基因的节律性降低和夜间蛋白质分解代谢紊乱有关。其中一些鉴定出的基因与人类的代谢功能障碍有关。
