理解细胞迁移可塑性的驱动力。
Understanding the driving force for cell migration plasticity.
机构信息
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland; Center for Cell Dynamics, Johns Hopkins University, Baltimore, Maryland.
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland; Center for Cell Dynamics, Johns Hopkins University, Baltimore, Maryland.
出版信息
Biophys J. 2023 Sep 19;122(18):3570-3576. doi: 10.1016/j.bpj.2023.04.008. Epub 2023 Apr 11.
Cell migration is a complex phenomenon. Not only do different cells migrate in different default modes, but the same cell can also change its migration mode to adapt to different terrains. This complexity has riddled cell biologists and biophysicists for decades in that, despite the development of many powerful tools over the past 30 years, how cells move is still being actively investigated. This is because we have yet to fully understand the mystery of cell migration plasticity, particularly the reciprocal relation between force generation and migration mode transition. Herein we explore the future directions, in terms of measurement platforms and imaging-based techniques, to facilitate the undertaking of elucidating the relation between force generation machinery and migration mode transition. By briefly reviewing the evolution of the platforms and techniques developed in the past, we propose the desirable features to be added to achieve high measurement accuracy and improved temporal and spatial resolution, permitting us to unveil the mystery of cell migration plasticity.
细胞迁移是一种复杂的现象。不仅不同的细胞以不同的默认模式迁移，而且同一细胞也可以改变其迁移模式以适应不同的地形。这种复杂性困扰了细胞生物学家和生物物理学家几十年，尽管在过去的 30 年中开发了许多强大的工具，但细胞如何运动仍在积极研究中。这是因为我们尚未完全了解细胞迁移可塑性的奥秘，特别是力的产生和迁移模式转变之间的相互关系。在此，我们探讨了未来的测量平台和基于成像的技术方向，以促进阐明力产生机制和迁移模式转变之间的关系。通过简要回顾过去开发的平台和技术的演变，我们提出了需要添加的理想特征，以实现高精度测量和提高时间和空间分辨率，从而揭示细胞迁移可塑性的奥秘。
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