MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK; Oncode Institute, Hubrecht Institute-KNAW, Utrecht, the Netherlands.
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
Dev Cell. 2020 Mar 9;52(5):550-562. doi: 10.1016/j.devcel.2020.02.013.
Motile cells have developed a variety of migration modes relying on diverse traction-force-generation mechanisms. Before the behavior of intracellular components could be easily imaged, cell movements were mostly classified by different types of cellular shape dynamics. Indeed, even though some types of cells move without any significant change in shape, most cell propulsion mechanisms rely on global or local deformations of the cell surface. In this review, focusing mostly on metazoan cells, we discuss how different types of local and global shape changes underlie distinct migration modes. We then discuss mechanical differences between force-generation mechanisms and finish by speculating on how they may have evolved.
游动细胞已经发展出多种依赖于不同牵引力生成机制的迁移模式。在细胞内成分的行为可以被轻易成像之前，细胞运动主要是根据细胞形状动力学的不同类型来分类的。事实上，尽管有些类型的细胞在移动时形状没有明显变化，但大多数细胞推进机制依赖于细胞表面的整体或局部变形。在这篇综述中，我们主要集中在后生动物细胞上，讨论了不同类型的局部和全局形状变化如何为不同的迁移模式提供基础。然后，我们讨论了力生成机制之间的力学差异，并推测它们可能是如何进化的。
