Craythorn J M, Swartz M, Creel D J
Retina. 1986 Winter-Spring;6(1):50-2.
Bull's-eye retinopathy has multiple associations. We report a case of bull's-eye retinopathy presumed to be secondary to clofazimine (Lamprene) treatment of a 30-year-old patient with acquired immunodeficiency syndrome (AIDS). Pretreatment baseline eye exam of this patient was normal except for bilateral cotton-wool spots. However, follow-up exam 5 months later revealed bilateral anterior pigmentary corneal deposits in a whorl pattern, a presumed infectious retinitis in the left eye, and bilateral annular macular pigmentary abnormalities. The patient was taken off clofazimine treatment, but died 1 month later. The authors suggest that patients being treated with clofazimine be examined for drug-related corneal and retinal lesions.
靶心状视网膜病变有多种关联情况。我们报告一例30岁获得性免疫缺陷综合征（AIDS）患者，其靶心状视网膜病变推测继发于氯法齐明（氯苯吩嗪，Lamprene）治疗。该患者治疗前的基线眼部检查除双侧棉絮斑外均正常。然而，5个月后的随访检查发现双侧角膜前色素沉着呈涡状，左眼疑似感染性视网膜炎，以及双侧环形黄斑色素异常。患者停用氯法齐明治疗，但1个月后死亡。作者建议，对接受氯法齐明治疗的患者应检查是否存在与药物相关的角膜和视网膜病变。
