Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China.
Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Sci Adv. 2023 Apr 14;9(15):eadf1043. doi: 10.1126/sciadv.adf1043. Epub 2023 Apr 12.
Switchable and minimally invasive tissue adhesives have great potential for medical applications. However, on-demand adherence to and detachment from tissue surfaces remain difficult. We fabricated a switchable hydrogel film adhesive by designing pattern-tunable wrinkles to control adhesion. When adhered to a substrate, the compressive stress generated from the bilayer system leads to self-similar wrinkling patterns at short and long wavelengths, regulating the interfacial adhesion. To verify the concept and explore its application, we established a random skin flap model, which is a crucial strategy for repairing severe or large-scale wounds. Our hydrogel adhesive provides sufficient adhesion for tissue sealing and promotes neovascularization at the first stage, and then gradually detaches from the tissue while a dynamic wrinkling pattern transition happens. The gel film can be progressively ejected out from the side margins after host-guest integration. Our findings provide insights into tunable bioadhesion by manipulating the wrinkling pattern transition.
可切换和微创组织粘合剂在医学应用中具有巨大的潜力。然而，要实现按需与组织表面的黏附和脱离仍然具有挑战性。我们通过设计图案可调的皱纹来控制黏附，从而制造出一种可切换的水凝胶薄膜粘合剂。当附着在基底上时，双层系统产生的压缩应力会导致短波长和长波长处出现自相似的褶皱图案，从而调节界面黏附力。为了验证这一概念并探索其应用，我们建立了一个随机皮瓣模型，这是修复严重或大面积创伤的关键策略。我们的水凝胶粘合剂为组织密封提供了足够的黏附力，并在第一阶段促进新血管生成，然后在发生动态褶皱图案转变时逐渐从组织上脱离。在主体-客体整合后，凝胶膜可以从边缘逐渐推出。我们的研究结果为通过操纵褶皱图案转变来实现可调生物黏附提供了新的思路。
