评价第四代皮下实时连续血糖监测仪（CGM）在腹膜透析糖尿病患者中的应用。
Evaluation of a Fourth-Generation Subcutaneous Real-Time Continuous Glucose Monitor (CGM) in Individuals With Diabetes on Peritoneal Dialysis.
机构信息
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.
Phase 1 Clinical Trial Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.
出版信息
Diabetes Care. 2023 Jun 1;46(6):1191-1195. doi: 10.2337/dc22-2348.
OBJECTIVE
To evaluate the performance of a real-time continuous glucose monitor (CGM) in individuals with diabetes on peritoneal dialysis (PD).
RESEARCH DESIGN AND METHODS
Thirty participants with type 2 diabetes on continuous ambulatory PD wore a Guardian Sensor 3 on the upper arm paired with Guardian Connect for 14 days. We compared CGM readings against Yellow Springs Instrument (YSI) venous glucose during an 8-h in-clinic session with glucose challenge.
RESULTS
The mean absolute relative difference (MARD) was 10.4% (95% CI 9.6, 11.7) from 941 CGM-YSI matched pairs; 81.3% of readings were within %15/15 of YSI values in the full glycemic range. Consensus error grid analysis showed 99.9% of sensor values in zones A and B. There were no correlations between pH, uremia, hydration status, and MARD.
CONCLUSIONS
We showed satisfactory performance of a real-time CGM sensor in PD patients with diabetes, supporting future use to facilitate treatment decisions.
目的
评估实时连续血糖监测仪（CGM）在腹膜透析（PD）糖尿病患者中的性能。
研究设计与方法
30 名接受持续流动腹膜透析的 2 型糖尿病患者在上臂佩戴 Guardian Sensor 3，并与 Guardian Connect 配对使用 14 天。我们在 8 小时的门诊检查中比较了 CGM 读数与 Yellow Springs Instrument（YSI）静脉血糖，并进行了葡萄糖挑战。
结果
941 对 CGM-YSI 匹配对的平均绝对相对差异（MARD）为 10.4%（95%CI 9.6，11.7）；在全血糖范围内，81.3%的读数与 YSI 值相差在 15%/15 以内。共识误差网格分析显示传感器值的 99.9%在 A 和 B 区。pH 值、尿毒症、水合状态与 MARD 之间无相关性。
结论
我们证明了实时 CGM 传感器在 PD 糖尿病患者中的性能令人满意，支持未来用于促进治疗决策。
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