关于 SNHG8 在人类疾病中的作用的综述。

A review on the role of SNHG8 in human disorders.

机构信息

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Pathol Res Pract. 2023 May;245:154458. doi: 10.1016/j.prp.2023.154458. Epub 2023 Apr 7.

DOI:10.1016/j.prp.2023.154458

PMID:37043963

Abstract

Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines. Its silencing has attenuated tumor growth in animal models of cancers. SNHG8 can be served as a molecular sponge for some miRNAs to regulate their target genes. miR-634/ZBTB20, miR-335-5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512-5p/TRIM28, miR-149-5p/PPM1F, miR-542-3p/CCND1/CDK6, miR-656-3p/SERBP1, miR-656-3p/SATB1, miR-1270/S100A11 and miR-384/HOXB7 are examples of molecular axes being regulated by SNHG8 in the context of cancer. Moreover, it can affect pathogenesis of atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke and myocardial infarction through modulation of a number of molecular axes such as SNHG8/miR-384/Hoxa13/FAM3A and miR-335/RASA1 as well as NF-κB signaling pathway. The current review aims at summarization of the role of SNHG8 in diverse human disorders.

摘要

小核仁 RNA 宿主基因 8（SNHG8）是一种长链非编码 RNA，在上皮细胞和肌肉卫星细胞中具有生理作用。据报道，这种 lncRNA 在多种癌细胞系中过度表达。其沉默减弱了癌症动物模型中的肿瘤生长。SNHG8 可以作为一些 miRNA 的分子海绵，调节它们的靶基因。miR-634/ZBTB20、miR-335-5p/PYGO2、miR588/ATG7、miR-152/c-MET、miR-1270/BACH1、miR-491/PDGFRA、miR-512-5p/TRIM28、miR-149-5p/PPM1F、miR-542-3p/CCND1/CDK6、miR-656-3p/SERBP1、miR-656-3p/SATB1、miR-1270/S100A11 和 miR-384/HOXB7 是 SNHG8 在癌症背景下调节的分子轴的例子。此外，它可以通过调节 SNHG8/miR-384/Hoxa13/FAM3A 和 miR-335/RASA1 以及 NF-κB 信号通路等许多分子轴，影响动脉粥样硬化、慢性脑缺血、急性痛风性关节炎、缺血性中风和心肌梗死的发病机制。本综述旨在总结 SNHG8 在多种人类疾病中的作用。