Tinoco J, Babcock R, Hincenbergs I, Medwadowski B, Miljanich P, Williams M A
Lipids. 1979 Feb;14(2):166-73. doi: 10.1007/BF02533868.
Linolenic acid deficiency has not been demonstrated clearly in warm blooded animals, yet circumstantial evidence suggests that n-3 fatty acids may have functions in these animals. The fact that several species of fish definitely require dietary n-3 fatty acids indicates that n-3 fatty acids have important and specific functions in these animals and suggests that such functions may also be present in warm blooded animals. It is also true that n-3 fatty acid distribution in tissues of birds and mammals appears to be under strict metabolic control, and that this complex metabolic control mechanism apparently has survived evolutionary pressure for a very long time. So far, attempts to produce linolenic acid deficiency in mammals have not revealed an absolute requirement for n-3 fatty acids. If functions for n-3 fatty acids do exist in warm blooded animals, it seems probable that they may be located in the cerebral cortex or in the retina, because these tissues normally contain high concentrations of n-3 fatty acids.
在温血动物中尚未明确证实亚麻酸缺乏，但间接证据表明n-3脂肪酸可能在这些动物中具有一定功能。几种鱼类明确需要膳食中的n-3脂肪酸，这一事实表明n-3脂肪酸在这些动物中具有重要且特定的功能，也暗示了此类功能可能在温血动物中同样存在。鸟类和哺乳动物组织中的n-3脂肪酸分布似乎受到严格的代谢控制，而且这种复杂的代谢控制机制显然在很长时间的进化压力下得以保留。到目前为止，在哺乳动物中制造亚麻酸缺乏的尝试尚未揭示对n-3脂肪酸的绝对需求。如果n-3脂肪酸在温血动物中确实存在功能，那么它们可能存在于大脑皮层或视网膜中，因为这些组织通常含有高浓度的n-3脂肪酸。
