Subramanian C S, Mead J F
Lipids. 1986 Sep;21(9):603-7. doi: 10.1007/BF02534059.
To test whether vitamin E deficiency might influence the course of essential fatty acid (EFA) deficiency, Long Evans rats were fed diets containing a marginal amount (1.5% of calories) of 18:2 omega 6 or 18:3 omega 3 fatty acid with complete absence of the other and with or without vitamin E. Vitamin E contents decreased continuously in serum and liver in all rats fed the E-free diets but in the brains of only the rats fed the marginal 18:3 omega 3, E-free diet. It is considered that the vitamin E is cooxidized in the liver with 22:6 omega 3, since this fatty acid is very low in livers of the rats fed the marginal 18:2 omega 6 diet but much higher in livers of the rats fed the marginal 18:3 omega 3 diet. Brain 22:6 omega 3 values are comparable for both groups. The source of 22:6 omega 3 is evidently in the mother's milk, since following weaning there is a precipitous drop in 22:6 omega 3 in serum, liver and carcass of rats on the 18:2 omega 6--containing diet. No significant signs of EFA deficiency were seen in the E-deficient rats.
为了测试维生素E缺乏是否会影响必需脂肪酸（EFA）缺乏的进程，给Long Evans大鼠喂食含有少量（占卡路里的1.5%）18:2ω6或18:3ω3脂肪酸且完全不含另一种脂肪酸的日粮，同时添加或不添加维生素E。在所有喂食无维生素E日粮的大鼠中，血清和肝脏中的维生素E含量持续下降，但仅在喂食少量18:3ω3无维生素E日粮的大鼠大脑中出现这种情况。据认为，维生素E在肝脏中与22:6ω3共同氧化，因为在喂食少量18:2ω6日粮的大鼠肝脏中这种脂肪酸含量非常低，但在喂食少量18:3ω3日粮的大鼠肝脏中含量要高得多。两组大鼠大脑中的22:6ω3值相当。22:6ω3的来源显然是母乳，因为断奶后，喂食含18:2ω6日粮的大鼠血清、肝脏和胴体中的22:6ω3会急剧下降。在维生素E缺乏的大鼠中未观察到明显的必需脂肪酸缺乏迹象。
