Ng Xin-Ning, Tsai Jen-Pi, Wang Chih-Hsien, Hsu Bang-Gee
Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
J Clin Med. 2023 Mar 26;12(7):2509. doi: 10.3390/jcm12072509.
Among hemodialysis (HD) patients, cardiovascular disease (CVD) is recognized as a major contributor to the high risk of mortality, and emerging evidence has ascertained arterial stiffness as an independent predictor of adverse cardiovascular (CV) outcomes. We aimed to investigate the efficacy of arterial stiffness measurement in predicting CV and all-cause mortality in patients on HD ( = 130). Carotid-femoral pulse wave velocity (cfPWV) was measured by a validated tonometry system. A cfPWV of >10 m/s was used to assign patients to the arterial stiffness group ( = 64). Baseline and biochemical characteristics, as well as all-cause and CV mortality, were recorded. During the 3-year follow-up period, a total of 32 deaths (25%) occurred. The patients who died had clinically significant high cfPWV levels; were relatively old; and had hypoalbuminemia, low creatinine levels, and diabetes. After adjustment for the prognostic variables, patients with elevated cfPWV had significantly higher all-cause ( = 0.036) and CV mortality ( = 0.017), compared with the mortality rates in the normal group. In this study, cfPWV was found to be an independent predictor of all-cause and CV mortality in HD patients.
在血液透析（HD）患者中，心血管疾病（CVD）被认为是导致高死亡率的主要因素，并且新出现的证据已确定动脉僵硬度是心血管（CV）不良结局的独立预测指标。我们旨在研究动脉僵硬度测量对预测HD患者（ = 130）的CV和全因死亡率的有效性。采用经过验证的眼压测量系统测量颈股脉搏波速度（cfPWV）。cfPWV>10 m/s用于将患者分配到动脉僵硬度组（ = 64）。记录基线和生化特征以及全因和CV死亡率。在3年的随访期内，共发生32例死亡（25%）。死亡患者的cfPWV水平在临床上显著升高；年龄相对较大；并且存在低白蛋白血症、低肌酐水平和糖尿病。在对预后变量进行调整后，与正常组的死亡率相比，cfPWV升高的患者全因死亡率（ = 0.036）和CV死亡率（ = 0.017）显著更高。在本研究中，发现cfPWV是HD患者全因和CV死亡率的独立预测指标。
