Hanoi Medical University Hospital, Hanoi Medical University, 1st Ton That Tung, Dong Da District, Hanoi 100000, Vietnam.
Department of Nutrition and Food Safety, School of Training Preventive Medicine and Public Health, Hanoi Medical University, 1st Ton That Tung, Dong Da District, Hanoi 100000, Vietnam.
Nutrients. 2023 Apr 4;15(7):1760. doi: 10.3390/nu15071760.
Multisystem inflammatory syndrome is associated with COVID-19 and can result in reduced food intake, increased muscle catabolism, and electrolyte imbalance. Therefore COVID-19 patients are at high risk of being malnourished and of refeeding syndrome. The present study aimed to determine the prevalence and correlates of malnutrition and refeeding syndrome (RS) among COVID-19 patients in Hanoi, Vietnam. This prospective cohort study analyzed data from 1207 patients who were treated at the COVID-19 hospital of Hanoi Medical University (HMUH COVID-19) between September 2021 and March 2022. Nutritional status was evaluated by the Global Leadership Initiative on Malnutrition (GLIM) and laboratory markers. GLIM-defined malnutrition was found in 614 (50.9%) patients. Among those with malnutrition, 380 (31.5%) and 234 (19.4%) had moderate and severe malnutrition, respectively. The prevalence of risk of RS was 346 (28.7%). Those with severe and critical COVID symptoms are more likely to be at risk of RS compared to those with mild or moderate COVID, and having severe and critical COVID-19 infection increased the incidence of RS by 2.47 times, compared to mild and moderate disease. There was an association between levels of COVID-19, older ages, comorbidities, the inability of eating independently, hypoalbuminemia and hyponatremia with malnutrition. The proportion of COVID-19 patients who suffered from malnutrition was high. These results underscore the importance of early nutritional screening and assessment in COVID-19 patients, especially those with severe and critical infection.
多系统炎症综合征与 COVID-19 相关，并可导致摄入减少、肌肉分解代谢增加和电解质失衡。因此，COVID-19 患者有发生营养不良和再喂养综合征的高风险。本研究旨在确定越南河内 COVID-19 患者营养不良和再喂养综合征（RS）的患病率和相关因素。这项前瞻性队列研究分析了 2021 年 9 月至 2022 年 3 月在河内医科大学 COVID-19 医院（HMUH COVID-19）接受治疗的 1207 名患者的数据。通过全球营养不良领导倡议（GLIM）和实验室标志物评估营养状况。根据 GLIM 定义，有 614 名（50.9%）患者存在营养不良。在营养不良患者中，分别有 380 名（31.5%）和 234 名（19.4%）患者患有中度和重度营养不良。RS 风险的患病率为 346 名（28.7%）。与轻度或中度 COVID 相比，患有严重和危重症 COVID 症状的患者更有可能有 RS 风险，与轻度或中度疾病相比，严重和危重症 COVID-19 感染使 RS 的发病率增加了 2.47 倍。COVID-19 水平、年龄较大、合并症、无法独立进食、低白蛋白血症和低钠血症与营养不良之间存在关联。患有营养不良的 COVID-19 患者比例较高。这些结果强调了对 COVID-19 患者，特别是严重和危重症感染患者进行早期营养筛查和评估的重要性。
