Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, Poland.
Department of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.
Molecules. 2023 Apr 5;28(7):3246. doi: 10.3390/molecules28073246.
The mutualistic coexistence between the host and endophyte is diverse and complex, including host growth regulation, the exchange of substances like nutrients or biostimulants, and protection from microbial or herbivore attack. The latter is commonly associated with the production by endophytes of bioactive natural products, which also possess multiple activities, including antibacterial, insecticidal, antioxidant, antitumor, and antidiabetic properties, making them interesting and valuable model substances for future development into drugs. The endophytes of higher plants have been extensively studied, but there is a dearth of information on the biodiversity of endophytic microorganisms associated with bryophytes and, more importantly, their bioactive metabolites. For the first time, we name bryophyte endophytes "bryendophytes" to elaborate on this important and productive source of biota. In this review, we summarize the current knowledge on the diversity of compounds produced by endophytes, emphasizing bioactive molecules from bryendophytes. Moreover, the isolation methods and biodiversity of bryendophytes from mosses, liverworts, and hornworts are described.
宿主和内生菌之间的互利共生关系是多样而复杂的，包括宿主生长调节、营养物质或生物刺激素等物质的交换，以及抵御微生物或草食动物攻击的保护。后者通常与内生菌产生具有多种活性的生物活性天然产物有关，这些天然产物具有抗菌、杀虫、抗氧化、抗肿瘤和抗糖尿病等活性，因此成为未来开发药物的有趣且有价值的模型物质。高等植物的内生菌已经得到了广泛的研究，但有关与苔藓植物相关的内生微生物的生物多样性，以及更重要的是它们的生物活性代谢物的信息却很少。我们首次将苔藓植物内生菌命名为“bryendophytes”，以详细阐述这一重要且多产的生物资源。在这篇综述中，我们总结了内生菌产生的化合物的多样性知识，强调了来自 bryendophytes 的生物活性分子。此外，还描述了苔藓植物、地钱植物和角苔植物内生菌的分离方法和生物多样性。
