Eshraghi Samani Reza, Safaee Masoumeh, Nematollahi Pardis, Amraei Babak
Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
Fellowship of Hematopathology, Associate Professor, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2023 Feb 25;12:34. doi: 10.4103/abr.abr_381_21. eCollection 2023.
The roles of Epstein-Barr virus (EBV) in breast cancer and breast lymphoma by transfecting EBV DNA have been indicated in different studies, but few investigations have been conducted on its roles in recurrence of breast cancer. Here, we aimed to evaluate the roles of EBV in recurrent breast cancer tissue.
This is a cross-sectional retrospective study that was performed in 2020-2021 in Isfahan on patients with breast cancer. The study population consisted of 30 tissue samples from recurrent breast cancer and 30 samples from nonrecurrent breast cancer. We collected demographic data of patients including age using a checklist. Other collected data were type of cancer, stages of cancer, tumor size in greatest dimension, lymph node involvements, and presence of metastasis. Furthermore, we evaluated all of the pathology samples from both groups for the presence of DNA of EBV and compared the data of both groups.
The DNA of EBV was positive in 8 patients of the relapsed group (26.6%) and 7 patients in the nonrelapsed patients (23.3%). There was no significant difference between two groups regarding positive DNA of EBV ( = 0.39). There were no significant differences between two groups of positive DNA of EBV with and without recurrent breast cancer regarding type of cancer ( = 0.63), stage of cancer ( = 0.19), tumor size in greatest dimension ( = 0.31), mean lymph node involvement ( = 0.27), number of lymph node involvement ( = 0.43), and metastasis ( = 0.69).
EBV might have no significant role in recurrence of breast cancer.
不同研究已表明，通过转染爱泼斯坦-巴尔病毒（EBV）DNA，EBV在乳腺癌和乳腺淋巴瘤中发挥的作用，但关于其在乳腺癌复发中的作用的研究较少。在此，我们旨在评估EBV在复发性乳腺癌组织中的作用。
这是一项于2020 - 2021年在伊斯法罕对乳腺癌患者进行的横断面回顾性研究。研究人群包括30例复发性乳腺癌组织样本和30例非复发性乳腺癌样本。我们使用清单收集患者的人口统计学数据，包括年龄。其他收集的数据有癌症类型、癌症分期、最大肿瘤尺寸、淋巴结受累情况和转移情况。此外，我们评估了两组所有病理样本中EBV DNA的存在情况，并比较了两组数据。
复发组8例患者（26.6%）的EBV DNA呈阳性；非复发组7例患者（23.3%）的EBV DNA呈阳性。两组在EBV DNA阳性方面无显著差异（P = 0.39）。在有或无复发性乳腺癌的两组EBV DNA阳性患者中，在癌症类型（P = 0.63）、癌症分期（P = 0.19）、最大肿瘤尺寸（P = 0.31）、平均淋巴结受累情况（P = 0.27）、淋巴结受累数量（P = 0.43）和转移情况（P = 0.69）方面均无显著差异。
EBV可能在乳腺癌复发中无显著作用。
