Barsukov A A, Zemskov V M, Beznosenko S A
Zh Mikrobiol Epidemiol Immunobiol. 1986 Jan(1):3-8.
Using the phenomenon of the formation of the active forms of oxygen by phagocytes in the process of adhesion, changes occurring in the cell membrane under the influence of sodium caseinate, macrophage migration inhibition factor, aggregated IgG and hydrolytic enzymes could be registered. Sodium caseinate inhibited chemiluminescence during the first 10 minutes in the adhesion of mouse peritoneal macrophages, human lung macrophages and adhesive marrow cells, while large doses of this preparation activated chemiluminescence at the latter stages of adhesion. Macrophage migration inhibition factor induced the rapid and prolonged formation of the active forms of oxygen in the process of macrophage adhesion, aggregated IgG decreased this cell function, and the subsequent phagocytosis of zymosan was accompanied by increased chemiluminescence. The experimental and practical possibilities of this phenomenon are discussed.
利用吞噬细胞在黏附过程中形成活性氧的现象，可以记录在酪蛋白酸钠、巨噬细胞移动抑制因子、聚集的免疫球蛋白G和水解酶影响下细胞膜发生的变化。酪蛋白酸钠在小鼠腹腔巨噬细胞、人肺巨噬细胞和黏附骨髓细胞黏附的最初10分钟内抑制化学发光，而大剂量的该制剂在黏附后期激活化学发光。巨噬细胞移动抑制因子在巨噬细胞黏附过程中诱导活性氧的快速和持续形成，聚集的免疫球蛋白G降低这种细胞功能，随后对酵母聚糖的吞噬伴随着化学发光增强。讨论了这一现象的实验和实际可能性。
