神经障碍中的神经回路变化：来自活体双光子成像的证据。
Neural circuit changes in neurological disorders: Evidence from in vivo two-photon imaging.
机构信息
Department of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China; Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Department of Neurology and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
出版信息
Ageing Res Rev. 2023 Jun;87:101933. doi: 10.1016/j.arr.2023.101933. Epub 2023 Apr 13.
Neural circuits, such as synaptic plasticity and neural activity, are critical components of healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing procedure affecting neuronal activities. Disruption of this essential process results in diseases. Advanced microscopic applications such as two-photon laser scanning microscopy have recently been applied to understand neural circuit changes during disease since it can visualize fine structural and functional cellular activation in living animals. In this review, we have summarized the latest work assessing the dynamic rewiring of postsynaptic dendritic spines and modulation of calcium transients in neurons of the intact living brain, focusing on their potential roles in neurological disorders (e.g. Alzheimer's disease, stroke, and epilepsy). Understanding the fine changes that occurred in the brain during disease is crucial for future clinical intervention developments.
神经回路，如突触可塑性和神经活动，是健康大脑功能的关键组成部分。神经回路的后续动态重塑是一个持续的过程，影响神经元活动。这个重要过程的破坏会导致疾病。最近，先进的显微镜应用，如双光子激光扫描显微镜，已被应用于了解疾病期间的神经回路变化，因为它可以在活体动物中可视化精细的结构和功能细胞激活。在这篇综述中，我们总结了评估完整活体大脑中突触后树突棘的动态重布线和神经元钙瞬变的最新工作，重点介绍了它们在神经疾病（如阿尔茨海默病、中风和癫痫）中的潜在作用。了解疾病期间大脑中发生的细微变化对于未来的临床干预发展至关重要。
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