Cerebral Cortex Research Group, Department of Cell and Network Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest 1083, Hungary.
Neuroscience Institute, School of Medicine, New York University, New York, NY 10016, USA.
Cell Rep. 2018 May 8;23(6):1706-1715. doi: 10.1016/j.celrep.2018.04.021.
Animals build a model of their surroundings on the basis of information gathered during exploration. Rearing on the hindlimbs changes the vantage point of the animal, increasing the sampled area of the environment. This environmental knowledge is suggested to be integrated into a cognitive map stored by the hippocampus. Previous studies have found that damage to the hippocampus impairs rearing. Here, we characterize the operational state of the hippocampus during rearing episodes. We observe an increase of theta frequency paralleled by a sink in the dentate gyrus and a prominent theta-modulated fast gamma transient in the middle molecular layer. On the descending phase of rearing, a decrease of theta power is detected. Place cells stop firing during rearing, while a different subset of putative pyramidal cells is activated. Our results suggest that the hippocampus switches to a different operational state during rearing, possibly to update spatial representation with information from distant sources.
动物会根据在探索过程中收集到的信息，建立周围环境的模型。后肢支撑会改变动物的观察视角，增加环境中被采样的区域。这种环境知识被认为会被整合到海马体存储的认知地图中。先前的研究发现，海马体损伤会损害后肢支撑。在这里，我们描述了在后肢支撑期间海马体的工作状态。我们观察到θ 频率增加，同时齿状回下陷，中间分子层出现明显的θ 调制快γ 瞬变。在后肢支撑的下降阶段，θ 功率下降。在支撑过程中，位置细胞停止放电，而另一组假定的锥体细胞被激活。我们的结果表明，海马体在支撑过程中切换到不同的工作状态，可能是为了用来自远距离的信息更新空间表示。
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