Guizhou Medical University, Guiyang, China.
Department of Urology, Guizhou Provincial People's Hospital, Guiyang, China.
BMC Microbiol. 2023 Apr 17;23(1):105. doi: 10.1186/s12866-023-02830-z.
Attenuated live bacterial therapy and medical BSA materials have their own advantages in anti-cancer research, and their combination is expected to overcome some of the disadvantages of conventional anti-cancer therapeutics.
Utilizing the high affinity between biotin and streptavidin, BSA modification on the surface of Escherichia coli (E. coli) was achieved. Then, the adhesion and targeting abilities of BSA modified E. coli was explored on different bladder cancer cells, and the underlying mechanism was also investigated.
BSA modification on the surface of E. coli enhances its ability to adhere and target cancer cells, and we speculate that these characteristics are related to the expression of SPARC in different bladder cancer cell lines.
BSA and live bacteria have their own advantages in anti-cancer research. In this study, we found that E. coli surface-modified by BSA had stronger adhesion and targeting effects on bladder cancer cells with high expression of SPARC. These findings pave the way for the future studies exploring the combination of BSA combined with live bacteria for cancer therapy.
减毒活细菌治疗和医学 BSA 材料在抗癌研究中各有优势，它们的结合有望克服传统抗癌疗法的一些缺点。
利用生物素和链霉亲和素之间的高亲和力，实现了 BSA 对大肠杆菌（E. coli）表面的修饰。然后，研究了 BSA 修饰的大肠杆菌在不同膀胱癌细胞上的黏附和靶向能力，并探讨了其潜在的作用机制。
BSA 修饰增强了 E. coli 黏附并靶向癌细胞的能力，我们推测这些特性与不同膀胱癌细胞系中 SPARC 的表达有关。
BSA 和活细菌在抗癌研究中各有优势。在本研究中，我们发现经过 BSA 表面修饰的大肠杆菌对高表达 SPARC 的膀胱癌细胞具有更强的黏附和靶向作用。这些发现为未来研究探索 BSA 与活细菌联合用于癌症治疗铺平了道路。
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