用于生物材料应用的蛋白质膜制备策略。
Strategies for Fabricating Protein Films for Biomaterials Applications.
作者信息
Gopalakrishnan Sanjana, Xu Jinlong, Zhong Fang, Rotello Vincent M
机构信息
Department of Chemistry, University of Massachusetts, Amherst, 710 N Pleasant St., Amherst, MA, 01002.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
出版信息
Adv Sustain Syst. 2021 Jan;5(1). doi: 10.1002/adsu.202000167. Epub 2020 Oct 11.
Proteins are naturally occurring functional building blocks that are useful for the fabrication of materials. Naturally-occurring proteins are biodegradable and most are biocompatible and non-toxic, making them attractive for the fabrication of biomaterials. Moreover, the fabrication of protein-based materials can be conducted in a green and sustainable manner due to their high aqueous solubility. Consequently, the applicability of protein-based materials is limited by their aqueous and mechanical instability. This review summarizes strategies for the stabilization of protein films, highlighting their salient features and potential limitations. Applications of protein films ranging from food packaging materials, tissue engineering scaffolds, antimicrobial coatings etc. are also discussed. Finally, the need for robust and efficient fabrication strategies for translation to commercial applications as well as potential applications of protein films in the field of sensing, diagnostics and controlled release systems are discussed.
蛋白质是天然存在的功能性结构单元，可用于材料制造。天然存在的蛋白质可生物降解，大多数具有生物相容性且无毒，这使其在生物材料制造方面具有吸引力。此外，由于蛋白质具有高水溶性，基于蛋白质的材料可以以绿色和可持续的方式进行制造。然而，基于蛋白质的材料的适用性受到其在水性环境中的不稳定性和机械性能不稳定的限制。本综述总结了稳定蛋白质膜的策略，突出了它们的显著特征和潜在局限性。还讨论了蛋白质膜在食品包装材料、组织工程支架、抗菌涂层等方面的应用。最后，探讨了将蛋白质膜转化为商业应用所需的强大而高效的制造策略，以及蛋白质膜在传感、诊断和控释系统领域的潜在应用。
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